放射治疗联合腔内热疗治疗鼻咽癌临床Ⅱ期试验  

Radiotherapy Combined with Intracavity Hyperthermia for Nasopharyngeal Carcinoma: A Phase Ⅱ Clinical Trial

作　　者：付真富[1] 陈伟军[2] 毛中萍[3] 王方正[2] 卢国文[2] 王建娥[2] 朱远[2] 马胜林[2] 

机构地区：[1]浙江大学,浙江杭州310004 [2]浙江省肿瘤医院,浙江杭州310022 [3]绍兴第二人民医院,浙江绍兴312000

出　　处：《肿瘤学杂志》2005年第3期195-197,共3页Journal of Chinese Oncology

摘　　要：[目的]探讨放射治疗联合腔内热疗治疗鼻咽肿瘤的耐受性、副反应和局部控制率。[方法]对42例首次治疗的鼻咽癌病例进行鼻咽腔内微波加热,每周1次,自放疗的第1周开始进行,每次持续50min,T90为42.5℃～43℃,共治疗4～7次,热敏电阻测量系统在治疗过程中全程实时监控,放射治疗采用6MV～10MV鄄X线常规照射。[结果]放射治疗联合腔内热疗治疗鼻咽癌的有效率为100%(CR95.2%,PR4.8%),肿瘤侵犯咽旁间隙者CR93.9%(31/33),鼻咽腔内肿瘤完全消退时的肿瘤剂量为32Gy～64Gy/16～32F,但急性重度黏膜反应(3～4级)发生率明显上升,达83.3%(35/42)。[结论]放射治疗联合腔内热疗治疗鼻咽癌能被患者所耐受,能改善局部控制率,尤其是能改善咽旁间隙受侵肿瘤的局部控制率。[Purpose] To evaluate the tolerance, side effect, and local control rate for nasopharyngeal carcinoma(NPC) treated with radiotherapy combined with intracavity hyperthermia. [Methods] Microwave intracavity hyperthermia was applied once a week for 42 initial treated NPC cases, once a week from the first week of radiotherapy, 50 minutes each time with T90 42.5℃～43℃ for 4~7 times. Thermistor measurement system was used for real time monitor during hyperthermia. 6MV^10MV-X ray was used during radiotherapy. [Results] Overall response rate for radiotherapy combined with intracavity hyperthermia in NPC was 100%(CR, 95.2%; PR, 4.8%), CR for carcinoma invaded parapharynegeal space was 93.9%(31/33 cases). The dose when carcinoma in nasopharyngeal cavity receded completely was 32Gy^64Gy/16F^32F, but acute severe mucosa response(3~4 grade)rate increased greatly(83.3%,35/42 cases). [Conclusions] Radiotherapy combined with intracavity hyperthermia was well tolerated in nasopharyngeal carcinoma patients and can improve local control rate, especially for patients with parapharyngeal space involvement.

关 键 词：鼻咽肿瘤 放射疗法 鼻腔 高温 诱发 

分 类 号：R739.63[医药卫生—肿瘤]