氟西汀合用心理行为干预治疗老年期抑郁症的疗效  

A study of curative effects of combined treatment in senile depression

作　　者：李玉凤[1] 姚丰菊[1] 杨福收[1] 李恒芬[1] 

机构地区：[1]新乡医学院第二附属医院,新乡453002

出　　处：《中国行为医学科学》2005年第6期494-495,共2页Chinese Journal of Behavioral Medical Science

基　　金：河南省教育厅科技攻关项目(20023200017)

摘　　要：目的探讨氟西汀合用心理行为治疗对老年期抑郁症的疗效。方法将50例老年期抑郁症随机分成两组,进行为期6周的对照研究,出院后随访1年,分别用心理行为合并氟西汀治疗(研究组)和氟西汀治疗(对照组);采用汉密尔顿抑郁量表(HAMD)和临床疗效总评量表(CGISI)进行评定。结果研究组在治疗6周后HAMD评分(9.51±2.35)较对照组(12.87±3.48)差异有显著性(P<0.01),研究组CGISI较对照组差异有显著性(P<0.01),1年末随访时HAMD评分研究组(9.21±2.74)较对照组(13.76±4.85)差异有显著性(P<0.01)。且研究组复发率低于对照组(P<0.05)。结论氟西汀合用心理行为治疗对老年期抑郁症的疗效优于单用氟西汀,且复发率低。ObjectiveTo explore the curative effects and prognoses of fluoxetine combined with psycho behavioral therapy in the senile depression.Methods50 patients with senile depression were randomly divided into study group(treated with fluoxetine combined with psycho behavioral therapy) and control group(with fluoxetine) for 6 weeks, and follow up conducted after discharge for one year and curative effects assessed with the HAMD and CGI SI.ResultsThere were significant differences in scores of both the HAMD(9.51±2.35) than in control group (12.87±3.48)(P<0.01), and that of in scores of both the CGI SI than in control group at the end of 6th weeks(P<0.01),and that of in scores of both the HAMD (9.21±2.74) than in control group ( 13.76 ±4.85) at the end of one year follow up(P<0.01).Recurrence rate was lower in the study group than in control group(P<0.05). Conclusion Combined therapy is better than single fluoxetine in senile depression, and has lower recurrence rate.

关 键 词：老年期抑郁症 心理行为干预治疗 氟西汀 汉密尔顿抑郁量表 心理行为治疗 HAMD 对照组 显著性 对照研究 临床疗效 复发率 出院后 评量表 CGI 随访 评分 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R57[医药卫生—临床医学]