缺氧诱导因子-1α、VEGF在脑出血灶周的表达研究  

Experimental study on expression of HIF-1α and its relationship to apoptosis in perihematoma with intracerebral hemorrhage

作　　者：唐洲平[1] 郭守刚[1] 黄秀梅 彭岚[1] 张苏明[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院神经内科,湖北武汉430030 [2]山东省金乡县卫生防疫站,山东金乡272200

出　　处：《中国现代医学杂志》2005年第9期1305-1307,共3页China Journal of Modern Medicine

基　　金：卫生部临床学科重点项目基金资助(NO.97070241)

摘　　要：目的探讨缺氧诱导因子-1α(hypoxiainduciblefactor-1α,HIF-1α)、(vascularendothelialgrouthfoutor,VEGF)在脑出血灶周中的表达,并探讨其表达的意义。方法应用免疫组织化学技术检测37例脑出血灶周脑组织中HIF-1α、VEGF的表达。结果37例脑出血灶周脑组织中HIF-1α阳性率为40.6%,HIF-1α在出血量>60mL时高表达,其阳性率为88.9%,与其他出血量(30￣45mL,45￣60mL)阳性率的表达比较有显著意义(P<0.05)。HIF-1α表达与手术时间明显相关,随着手术时间的推迟而增加,差别有显著性意义(P<0.05)。HIF-1与VEGF的表达呈正相关(n=15,r=0.79)(P<0.01)。结论脑出血后HIF-1α的表达与出血量及手术时间相关,为判断脑出血灶周缺血半暗带的存在提供了依据;HIF-1α与脑出血后微循环的重建有关。[Objective]To evaluate expression of HIF-1α and VEGF in perihematoma with intracerebral hemorrhage. Expression of HIF-1α and VEGF were assessed by inmunohistochemistry straining In 37cases of hypertensive hemorrhage., positive rate for HIF-1α was 40.6%, specially the positive rate of the volume of hematoma >60 mL (88.9%) was significantly higher than others volume of hematoma. HIF-1αexpression increased as the hematoma volume and operation time increased (P <0.05). There were a positive correlation between HIF-1α labeling index and VEGF index (n =12, r =0.79). [Conclusions] Expression of HIF-1αwas closely relate with the time of hemorrhage, it provide a foundation that the ischemic penumbra exist in the perihematoma

关 键 词：脑出血 缺氧诱导因子-1Α VEGF 

分 类 号：R743.34[医药卫生—神经病学与精神病学]