从2260m移居4300m人体红细胞2,3-二磷酸甘油酸浓度及有关指标的变化  

Change of RBC 2, 3-DPG level in healthy subjects migrated from 2 260 m to 4 300 m

作　　者：格日力[1] 陈秋红[1] 佘海茹 和伦高娃 吴天一[1] 小林俊夫 久保惠嗣[2] 

机构地区：[1]青海省高原医学科学研究所,西宁810012 [2]日本信州大学医学部

出　　处：《中华航空医学杂志》1994年第2期101-103,共3页

摘　　要：观察了13名健康被试者（男8名，女5名）从海拔2260m移居4300m后14天，红细胞2，3-二磷酸甘油酸（2，3－DPG）浓度及血气参数的变化，并与世居4300m的24名藏民进行比较，以探讨2，3－DPG在急进高原适应过程中的作用。结果显示，13名被试者于2260m时红细胞2，3－DPG为4．30±0.81mmol／L，移居4300m后14天为5．05±0．83mmol／L，增加了172％（t=4．29，P＜0．01）；比当地藏民（4．49±0．06mol／L）高12．4％（t=2．33，P＜0．05）。移居4300m后血液pH增加、PaCO2和PaO2降低（P＜0．01），红细胞压积也明显增加（P＜0．05）；但与当地藏民比较，血气备指标无显著性差异。结果提示，进入高原后，红细胞2，3－DPG的适当增加是机体对低氧环境适应的生理反应。The level of 2, 3-DPG and blood gas were measured in 13 healthy subjects before and after migrating from 2 260 m to 4 3oo m, and compared with those of natives lived at 4 300 m (24Tibetans). The results showed that the level of 2, 3-DPG of red blood cell (RBC) was 4. 30±0. 81mmol/L at 2260 m and increased to 5.0±0. 83 mmol/L after 14 d residence at 4 300 m(P<0. 01).The later was significantly higher (12. 47 %) than that of the natives (4. 49± 0. 06 mmol/L) (P<0. 05).It was also found that in subjects after 14 d residence at 4 300 m blood pH value was significantly ligherthan that at 2 260 m,while PaCO2 and PaO2 were signifitantly lowered,but they were not significantlydifferent from those of the natives. It is suggested that the increase of 2,3-DPG of RBC in human mi-grated to highland is a physiological reaction in adapting hypoxic environment.

关 键 词：高山病 红细胞 二磷酸甘酸 血气分析 

分 类 号：R594.302[医药卫生—内科学]