偏侧帕金森病猴模型的脑血流灌注SPECT在体显像研究  

IN VIVO TOMOGRAPHIC STUDY OF CEREBRAL BLOOD PERFUSION WITH SPECT IN HEMIPARKINSONIAN MONKEYS

作　　者：陈生弟[1] 周孝达[1] 徐德隆[1] 朱承谟[1] 张冀先[1] 国毓智[1] 匡琴芳[1] 李彪[1] 

机构地区：[1]上海第二医科大学瑞金医院神经科,上海第二医科大学仁济医院神经科,上海第二医科大学瑞金医院核医学科,江苏省原子医学研究所

出　　处：《中华核医学杂志》1994年第4期209-210,共2页Chinese Journal of Nuclear Medicine

基　　金：国家自然科学基金

摘　　要：给恒河猴右侧颈内动脉注射神经毒素１－甲基－４－苯基－１，２，３，６－四氢吡啶后，产生右侧黑质神经元脱失、黑质纹状体多巴胺浓度明显降低以及左侧帕金森样症状．给予抗帕金森病药物治疗后帕金森样症状明显改善．进行偏侧帕金森病猴模型ＳＰＥＣＴ脑血流灌注显像，发现猴模型建立３个月时损毁侧脑血流灌注量明显减低，８个月时损毁侧脑血流灌注量转为正常．结果表明脑血流灌注的变化反映了帕金森病的病理生理变化过程．Abstract We present data on the utility of tunctional brain imaging with￣(99m)Tc-ECD and SPECT in the study of MPTP induced hemiparkinsonism in monkeys.Injection of MPTP into the right common carotid artery of 10 rhesus monkeys produced hemiparkinsonism in the contralateral limbs which responded to antiparkinsonian medication. The unilateral neurotoxicity of the MPTP treated side was confirmed biochemically by marked reduction of DA contents in the nigrostriatum and histologically by selective neuronal loss in the substantia nigra.These monkeys with hemiparkinsonism were studied with SPECT using^(99m)Tc-ECD as perfusion marker.The results of brain scanning showed that the cerebral blood perfusion of MPTP treated side was significantly depleted 20～ 90 days after MPTP intoxication,and returned to normal 8 monthes after perfusion.The experiment indicates that abnormal cerebral blood perfusion is involved in the course of parkinsonian pathophysiology.

关 键 词：放射性 脑 血液供给 同位素成像 震颤性麻痹 CT 

分 类 号：R742.502[医药卫生—神经病学与精神病学]