血清可溶性白细胞介素2受体表达与急性淋巴细胞性白血病复发的关系  

Relation between the expression of sIL-2R and the relapse in patients with acute lymphoblastic leukemia

作　　者：柳金[1] 吴登蜀[2] 张伸[3] 阎晨华[3] 周宇[1] 张永顶[1] 齐振华[2] 

机构地区：[1]北京大学深圳医院血液科,深圳518036 [2]中南大学湘雅医院血液科 [3]北京大学血液病研究所,人民医院血液科

出　　处：《北京大学学报（医学版）》2005年第3期249-251,共3页Journal of Peking University:Health Sciences

基　　金：深圳市科技局科研基金(20004093)资助~~

摘　　要：目的: 探讨血清可溶性白细胞介素2受体(solubilityinterleukinreceptor,sIL 2R)表达水平与急性淋巴细胞性白血病(acutelymphoblasticleukemia,ALL)复发的关系。方法:采用双抗体夹心酶联免疫吸附法,检测48例ALL患者初诊、复发未治疗前及第1次完全缓解后sIL 2R表达水平。结果:ALL初诊组和复发组sIL 2R表达水平显著高于正常对照组,而在ALL缓解组与正常人比较,差异没有统计学意义;初诊或复发组患者sIL 2R水平显著高于缓解组;动态观察30例患者发现,治疗有效达到完全缓解时sIL 2R水平明显下降, 而病情复发时患者sIL 2R水平显著上升,sIL 2R水平上升出现在骨髓细胞形态学确诊之前一个月左右。结论:动态检测完全缓解后患者sIL 2R表达水平,有利于ALL复发早期诊断。Objective: To explore the relation of the serum level of sIL-2R in relapse patients with acute lymphoblastic leukemia(ALL). Methods:With ELISA, we determined the levels of sIL-2R of 48 patients with ALL after their first diagnoses,complete remission 1 and relapse. The levels of sIL-2R of 30 patients from complete remission 1 to relapse were monitored. Results: The levels of sIL-2R were higher in the relapse group and first diagnosed group than in the control. The levels of sIL-2R were higher in the relapse group and first diagnosed group than in the complete remission 1 group. However,the difference between the complete remission 1 and the control had no statistical significance. When we determined the levels of sIL-2R dynamically, we found that after complete remission ,the levels of sIL-2R decreased,however, before one month of hematological relapse, the levels of sIL-2R increased. Conclusion: Monitor of the level of sIL-2R can predict impending relapse of patients with ALL and is helpful to early diagnosis of relapse.

关 键 词：白血病复发 血清可溶性白细胞介素2受体 SIL-2R水平 受体表达 双抗体夹心酶联免疫吸附法 急性淋巴细胞性白血病 receptor 骨髓细胞形态学 正常对照组 ALL 患者发现 动态观察 完全缓解 病情复发 动态检测 早期诊断 缓解后 

分 类 号：R733.7[医药卫生—肿瘤] R767.1[医药卫生—临床医学]