噻氯匹啶对急性脑梗塞病人血小板聚集的抑制作用  

The Inhibitory Effect of Ticlopidine on Platelets Aggregation in Treatment of Acute Cerebral Infarction

作　　者：彭化生 郭桂云 

机构地区：[1]菏泽地区第三人民医院,274031

出　　处：《菏泽医学专科学校学报》1999年第1期14-16,共3页Journal of Heze Medical College

摘　　要：目的　观察国产噻氯匹啶对急性脑梗死病人血小板聚集的抑制作用；方法　选择９８ 例急性脑梗死病人，随机分为噻氯匹定组和阿司匹林组，噻氯匹啶组用噻氯匹啶，阿司匹林组用阿司匹林，数据用方差分析，差异性用ｔ 检验；结果　２ 组用药后与用药前相比血小板聚集率均明显下降，（ Ｐ＜ ０ ．０１） ，而２ 组间比较噻氯匹啶的作用大于阿司匹林（ Ｐ＜ ０ ．０５） ；结论　国产噻氯匹定对急性脑梗死病人的血小板聚集有肯定的抑制作用。Objective To observe the inhibitory effect of domestic ticlopidine on platelets gathering in patients with acute cerebral infaction. Methods Ninty eight patients with acute cerebral infarction were divided into 2 groups: 49 patients ( M 32, F 17, aged 59+ s7a) received ticolpidine . Other 49 patients as control group(M 35, F 14,aged 60+s8a) received aspirin .The course of therapy were 4 weeks. Results The platelets aggregative rates of 2 groups were both significantly reduced before and after treatments(P<0.01).The effect of ticolpidine was greater than that of aspirin. Conclusion Domestic ticolpidine has a certain inhibitory effect on platelets aggregation in patients with acute cerebral infarction.

关 键 词：急性脑梗死/治疗 噻氯匹啶/治疗应用 阿司匹林/治疗应用 血小板聚集/血液 

分 类 号：R743.3[医药卫生—神经病学与精神病学]