安氟醚吸入与预注爱肌松对其肌松时效的影响  

Effect of enflurane and the priming dose of alloferin on its time-effects of muscle relaxion.

作　　者：吕国义[1] 杨轶 史可梅[1] 武岩[1] 薛玉良[1] 邓迺封[1] 

机构地区：[1]天津医学院第二医院麻醉科,邮政编码300211 [2]秦皇岛市第一人民医院外科

出　　处：《中华麻醉学杂志》1994年第5期342-343,共2页Chinese Journal of Anesthesiology

摘　　要：单次静注爱肌松（０．３ｍｇ·ｋｇ－１，对照组）于３．１７±０．８１分钟（ｘ±ｓ）可获得满意的气管插管条件。预注组（１０例）首次量０．２７ｍｇ·ｋｇ－１于预注剂量（０．０３ｍｇ·ｋｇ－１）后５分钟给予，可使爱肌松的起效时间缩短至０．９３±０．１７分钟（Ｐ＜０．００１），ＴＯＦ无反应期、２５％和９０％恢复时间两组无显著差别（Ｐ＞０．２５）。全部病例均获得了良好的气管插管条件，预注的优点还在于能评估患者对所选用非去极化肌松药的敏感性。预往后ＴＯＦ肌电图Ｔ１抑制＞１０％较无明显ＴＯＦ抑制者肌松恢复时间显著延长（Ｐ＜０．０５）。同时发现吸入安氟醚可使爱肌松作用时效延长。A satisfactory condition for tracheal intuhation in 3.17±O. 81min could be pro- ided with a single dose of alloferin 0. 3mg/kg in 6 patients as control group. An initial dose of alloferin 0. 27mg/kg was given 5 minutes after a priming dose of 0. 03mg/kg iv in other (10 patients ) group, the onset time of alloferin for intubation was shortened to 0. 93 ±0. 17min (P< O. 001 ),the total paralysis duration and 25% and 7o% recovery time were not different between the two groups. Good nditions that facilitated the endotracheal intubation were achieved in all patients. An added advantage of 'priming' is that the patient's sensitivity to nondepolarizing muscle relaxants can be estimated by observing the response to the Priming dose. The duration of muscular relaxation had been doubly prolonged when enflurane was inhaled simultane- ously.

关 键 词：爱肌松 预注剂量 肌松时效 

分 类 号：R614.1[医药卫生—麻醉学]