^（131）I－抗膀胱癌单克隆抗体对荷瘤裸鼠的放射免疫治疗研究  

Radioimmunotheraphy of nude mice bearing human bladder carcinoma with ￣(131)I-anti-BIU-87 McAb

作　　者：张春丽[1] 俞莉章[1] 赵翀[1] 谢蜀生[1] 顾方六[1] 朱绍莉[1] 潘中允[1] 

机构地区：[1]北京医科大学第一医院核医学科,北京医科大学泌尿外科研究所,北京医科大学免疫教研室

出　　处：《中华泌尿外科杂志》1994年第1期3-5,共3页Chinese Journal of Urology

基　　金：国家教委高校博士点专项基金

摘　　要：用^（１３１）Ｉ标记的抗ＢＩＵ－８７ＭｃＡｂ对荷人膀胱癌裸鼠进行放射免疫治疗，结果显示对肿瘤有明显的抑制作用。高剂量组（１４８００ｋＢｑ组）疗效明显优于低剂量组（７４００ｋＢｑ组），其治疗后第４周对肿瘤的抑制率分别为９９％及７２％。未发现１４８００ｋＢｑ^（１３１）Ｉ－抗ＢＩＵ－８７ＭｃＡｂ对小鼠产生毒性。Radioimmunotheraphy of nude mice bearing human bladder carcinoma using 131I-anti-BIU-87McAb has been studied. The results showed that 131I-anti-BIU-McAb effectively inhibited tumor growth. The therapeutic efficacy of high dosage group ( 400μCi group) was much higher than that of low dosage group (200μCi group). The inhibition ratio of tumor in 4 weeks post injection were 99%and 72% for the above groups respectively. No toxic effects has been noted.

关 键 词：膀胱肿瘤 癌 裸鼠 单克隆抗体 

分 类 号：R737.140[医药卫生—肿瘤]