Biological effects of radioactive ~9C-ion beams on cells  

作　　者：WEIZengquan LIQiang A.Kitagawa T.Kanai M.Kanazawa Y.Furusawa E.Urakabe XIEHongmei ZHOUGuangming 

机构地区：[1]InstituteofModernPhysics,ChineseAcademyofSciences,Lanzhou730000,China [2]InstituteofModernPhysics,ChineseAcademyofSciences,Lanzhou730000,China//NationalInstituteofRadiologicalSciences,Chiba263-8555,JapanCorrespondenceshouldbeaddressedtoWeiZengquan [3]NationalInstituteofRadiologicalSciences,Chiba263-8555,JapanCorrespondenceshouldbeaddressedtoWeiZengquan

出　　处：《Chinese Science Bulletin》2005年第11期1070-1075,共6页

摘　　要：The distinguishing feature and current technique progress of tumor treatment with heavy-ion beams is introduced in the paper. Additional superiority to tumor treatment from a radioactive ion beam (RIB) is emphatically discussed. The experimental research of the radioactive 9C-ion beams aimed at tumor treatment at Heavy Ion Medical Accelerator in Chiba (HIMAC), National Institute of Radiological Sciences (NIRS), Japan is described in detail, La-eluding production of the beams, optimization of parameters, distribution of depth dose, survival effect of cell and comparison of RBE between 9C- and 12C-beams. Results show that under 40 mm thick Beryllium target and 10 mm thick aluminum degrader at full (5%) momentum acceptance, the production rate and purity of the produced 9C-beams are 9.07×10-6 and 82.88% respectively with the primary 12C-beams of 430 MeV/u and 1.8×109 pps. A uniform irradiation field with homogeneity up to 89.6% inside central area 10 mm in diameter is obtained by using spot scanning. In this case, the dose rate at the entrance is 0.5 Gy/h. In survival experiment of cells, the average relative biological effectiveness (RBE) of 9C-beams is 5.28 and 2.93 for 12C-beams in the region around Bragg peak. The RBE of 9C-beams is 1.8 times higher than that of 12C-beams. It indicates that cell-killing efficiency of 9C-beams is stronger than that of 12C-beams. 9C-beams are more efficacious for tumor treatment than 12C-beams.The distinguishing feature and current technique progress of tumor treatmentwith heavy-ion beams is introduced in the paper. Additional superiority to tumor treatment from aradioactive ion beam (RIB) is emphatically discussed. The experimental research of the radioactive^9C-ion beams aimed at tumor treatment at Heavy Ion Medical Accelerator in Chiba (HIMAC), NationalInstitute of Radiological Sciences (NIRS), Japan is described in detail, including production of thebeams, optimization of parameters, distribution of depth dose, survival effect of cell andcomparison of RBE between ~9C- and ^(12)C-beams. Results show that under 40 mm thick Berylliumtarget and 10 mm thick aluminum degrader at full (5%) momentum acceptance, the production rate andpurity of the produced ~9C-beams are 9.07x10^(-6) and 82.88% respectively with the primary^(12)C-beams of 430 MeV/u and 1.8x10^9 pps. A uniform irradiation field with homogeneity up to 89.6%inside central area 10 mm in diameter is obtained by using spot scanning. In this case, the doserate at the entrance is 0.5 Gy/h. In survival experiment of cells, the average relative biologicaleffectiveness (RBE) of ~9C-beams is 5.28 and 2.93 for ^(12)C-beams in the region around Bragg peak.The RBE of ~9C-beams is 1.8 times higher than that of ^(12)C-beams. It indicates that cell-killingefficiency of ~9C-beams is stronger than that of ^(12)C-beams. ~9C-beams are more efficacious fortumor treatment than ^(12)C-beams.

关 键 词：生物学 放射性粒子束 参数优化 生存能力 肿瘤细胞 治疗方法 

分 类 号：R730.55[医药卫生—肿瘤]