肺小细胞癌的综合治疗研究  

NON-SURGICAL TREATMENT FOR SMALL CELL LUNG CANCER WITHCHEMO-RADIO-IMMUNOTHERAPY AND TRADITIONAL CHINESE MEDICINE

作　　者：查人俊 何长清[1] 曾逖闻[1] 陈树森[1] 李维华[1] 王淑敏[1] 常庆森[1] 赵会泽.姚晨 黄孝迈[1] 

机构地区：[1]中国人民解放军总医院

出　　处：《中华内科杂志》1994年第7期462-466,共5页Chinese Journal of Internal Medicine

摘　　要：肺小细胞癌经长期、间歇、ＶＣＭＢ为主的联合化疗和根治性放疗，以及中西医药综合治疗５４例，并做了连续追踪观察，结果完全缓解率为５９．２％部分缓解率为３８．９％总有效率达９８．１％．按Ｋａｐｌａｎ－Ｍｅｉｅｒ法计算，１、３、５年生存率局限期分别为７８．１％４２．６％和３２．１％广泛期分别为９０．５％，１３．４％１３．４％；4 consecative cases of small cell lung cancer(SCLC) were treated with longterm short-intervalcombined treatment modalities of chemotherapy,radiotherapy (55-65 GY),immunotherapy, tradition-al Chinese medicine(leaf of Asiatic Ginseng, root of Astragalus membranaceus Bge,etc)and otheradjuvants. Chemotherapy consisted of vincristine,cyclophosphamide,methotrexate and carmustine,Acomplete response of 59.2%,partial response of 38.9% and an overall response of 98.1 % were achieved.According to Kaplan-Meier,the survival rates of SCLC with limited disease for 1,3, 5 and 10 yearswere 78.1%,42.6%, 32.1 % and 21.4% respectively:while those with extensive disease for 1,3 and 5years 90.5%, 13.4% and 13.4%。According to classification of international TNM staging(1988), thesurvival rates of stage II SCLC for 1,3, 5 and 10 years were 92.9%, 61.9%,53.1 % and 31.8%respectively; of stage IIIa for 1,3 and 5 years 80.0%,30.0% and 20.0%, and of stage IIIb 83.3%,20.8%and 15.6%。Our combined modalities raised the survival rates considerably;the improved effect wasmainly due to the long-term (especilly more than 2 years or 10 courses),short-interval,effective andtimely combined treatment with chemotherapy,radiotherapy and adjuvants such as traditional Chinesemedicine and immunotherapy. By using the above therapeutic strategy,10 out of 12 SCLC patients in-cluding 4 with extensive disease,who were relatives of our hospital staffs, have gained more than 3～17years of survival.Therefore small cell lung cancer even with extensive disease was a hopeful curable dis-ease.

关 键 词：肺肿瘤 小细胞癌 综合疗法 

分 类 号：R734.205[医药卫生—肿瘤]