乙双吗啉相关性白血病  

LEUKEMIA ASSOCIATED WITH BIMKOLANE

作　　者：叶辉[1] 屠振华[1] 李兴福[1] 宋素琴[1] 王正起[1] 

机构地区：[1]山东省滕州市中心人民医院内科,山东医科大学附属医院血液病研究室

出　　处：《中华内科杂志》1994年第10期669-671,共3页Chinese Journal of Internal Medicine

摘　　要：观察了乙双吗啉对银屑病患者及小鼠的影响。用药组１１例病人的染色体畸变率及细胞微核率均高于对照组１１例病人（Ｐ分别＜０．０５；＜０．０１）。外周血　淋巴细胞比值用药组明显降低（Ｐ＜０．０５）。血ＩｇＭ用药组低于对照组（Ｐ＜０．０５）。观察组４０只小鼠，１０只发生了白血病（７例为急性早幼粒细胞白血病），对照组２０只同种系小鼠未发生白血病，两组发病率差异显著（Ｐ＜０．０５）。soriatic patients and mice treated with bimolane were observed. The frequency of chromosomes aberration and micro- nuclear cells presence in the treated group(11 cases) was sigificantly higher than that in the control group(11 cases, P<0.005; <0.001 ).Study of lymphocytic subsets showed that value of CD_4/CD_8 in the peripheral blood of the treated group was lower than that of the control group(P<0.05).The level of serum IgM in the treated group was also lower (P<0.05);There were 10 mice suffering from leukemia(7 mice with acute premyelocytic leukemia in a treated group of 40 mice of an inbred line of 615 mice,while there was no leukemia in a coutrol group of 20 mice of the same species.The morbidity of leukemia in the treated mice was higher than that of controls(P<0.05).

关 键 词：白血病 乙双吗啉 银屑病 

分 类 号：R733.702[医药卫生—肿瘤]