中枢神经细胞瘤研究进展  

Research advance of central neurocytoma

作　　者：徐红超[1] 陈忠平[1] 周旺宁[1] 

机构地区：[1]中山大学肿瘤防治中心神经外科,广州510060

出　　处：《中华神经医学杂志》2005年第6期639-641,共3页Chinese Journal of Neuromedicine

摘　　要：中枢神经细胞瘤是一种少见的神经元来源的脑室内肿瘤,大多呈良性,预后良好。其组织学病理特征为肿瘤细胞来源相同、体积小、大小一致、排列紧密。磁共振波谱特征包括胆碱增高、肌酸和N-乙酰天门冬酸盐减少。最佳的治疗方法是手术治疗,术后辅助放疗、化疗可以提高局部控制率或患者的生存率以及降低复发率。MIB-1标记指数在提示预后上价值较大。本文就近年来其影像、病理和临床等方面的研究进展做一综述。Central neurocytomas are rare intraventricular neuronal neoplasms of the central nervous system. Typically,they are benign tumors and patients with central neurocytomas have a favorable prognosis. The central neurocytoma is composed of homogenous,small uniform cells. General patterns of the proton magnetic resonance of central neurocytoma include elevated choline,decreased creatine and NAA. The most effective therapeutic modality is surgery,and adjuvant radiation therapy and chemotherapy can be added to improve local control or increase survial,and decrease recurrent rate. The proliferation markers MIB-1 is useful in predicting relapse. This paper summarizes the recent advances in imaging,neuropathology and clinical theraphies.

关 键 词：中枢神经细胞瘤 术后辅助放疗 脑室内肿瘤 局部控制率 MIB-1 细胞来源 病理特征 波谱特征 N-乙酰 手术治疗 治疗方法 标记指数 神经元 组织学 磁共振 天门冬 复发率 生存率 临床等 预后 

分 类 号：R739.4[医药卫生—肿瘤]