X-刀开放瘤周血脑屏障后化学治疗脑部恶性肿瘤  

Chemotherapy after blood-brain barrier disruption caused by X-knife radiotherapy for malignant brain tumors

作　　者：俞方毅[1] 刘承勇[1] 漆松涛[1] 

机构地区：[1]南方医科大学南方医院神经外科,广东广州510515

出　　处：《中国微侵袭神经外科杂志》2005年第6期247-248,共2页Chinese Journal of Minimally Invasive Neurosurgery

摘　　要：目的探讨X-刀联合全身化疗治疗脑部恶性肿瘤的具体方法和临床疗效。方法选择脑部恶性肿瘤病人52例,随机分为联合治疗组(n=31)和单纯X-刀治疗组(对照组,n=21)。联合治疗组在X-刀治疗3周后行多个疗程的全身盐酸尼莫司汀(ACNU)治疗;对照组仅采用X-刀治疗,比较两组治疗效果。结果①两组在X-刀治疗3周后均可观察到血脑屏障、脑肿瘤屏障开放。②60周时联合治疗组29例(93.5%)生存,对照组14例(66.7%)生存,差异有统计学意义(P<0.05)。结论采用X-刀治疗脑部恶性肿瘤,增强了化疗效果,两者联用有助于提高病人的生存率。ive: Objective To study the specific method and curative efficacy of chemotherapy combined with X-knife radiotherapy for malignant brain tumors. Methods Fifty-two patients were randomly divided into combined therapy group with 31 cases and contrast group with 21 cases. The patients were treated by several courses of Nimustine (ACNU) after X-knife radiotherapy, while the patients of contrast group only treated with X-knife. The curative effect was compared between two groups. Results ①Blood-brain barrier disruption and blood-tumor disruption was observed in all patients 3 weeks after X-knife treatment. ②Twenty-nine cases (93.5%) of combined therapy group survived 60 weeks after treatment, while the number is fourteen (66.7) in contrast group. There is a statistical difference, P < 0.05. Conclusion X-knife treatment may enhance the curative efficacy of chemotherapy for malignant brain tumors, and survival rate may increased by combined therapy.

关 键 词：放射外科手术 抗肿瘤联合化疗方案 血脑屏障 脑肿瘤 

分 类 号：R739.4[医药卫生—肿瘤]