润坦注射液治疗血管性痴呆的临床观察  

Vinpocetine in the treatment of vascular dementia

作　　者：张乐[1] 杨期东[1] 杜小平[1] 

机构地区：[1]中南大学湘雅医院神经内科,长沙410008

出　　处：《卒中与神经疾病》2005年第3期155-157,共3页Stroke and Nervous Diseases

摘　　要：目的探讨润坦注射液(长春西汀,Vinpocetine)对血管性痴呆(vasculardementia,VD)的疗效及其作用机制。方法对随机双盲法给药的老年VD患者(润坦注射液组35例,一般治疗组33例)分别在治疗第7、14、21d进行精神状态检查法(MMSE)评分,同时测定与学习记忆相关的乙酰胆碱酯酶(AchE)活性,并与正常组对照观察。结果润坦注射液组VD患者在第21d的MMSE评分显著高于治疗前及一般治疗组,且润坦注射液组VD患者的乙酰胆碱酯酶(AchE)活性降低,红细胞(RBC)和血浆乙酰胆碱(Ach)含量升高。结论润坦注射液治疗老年VD患者疗效肯定,且与治疗时间有关,增强VD患者胆碱能神经系统功能可能是其治疗机理之一。Objective To explore the effect and therapeutic mechanism of Vinpocetine in treating vascular dementia.Methods The score of MMSE and the activity of cholinergic nerve system in 68 old patients with VD (35 cases in vinpocetine group, 33 cases in common group) were detected and compared with control group in 7,14 and 21 days respectively.Results The scores of MMSE of vinpocetine group were significantly higher than those of common group.Vinpocetine could decrease the activity of cholinesterase and improve content of acetylcholine in RBC and plasm in 21 days.Conclusions Vinpocetine has definite effect on VD,which may be related to the therapeutic time and the mechanism in improving the function of cholinergic nerve system.

关 键 词：润坦注射液 血管性痴呆 胆碱能神经系统 

分 类 号：R749.13[医药卫生—神经病学与精神病学]