SARS流行期间预防用药不良反应分析与比较  

Analysis and comparison of ADRs of precautionary medication during the epldemic of SARS

作　　者：翟伟[1] 张俊[1] 李群娜[1] 裴振峨[1] 闫炜[1] 张京航[1] 邓培媛[1] 

机构地区：[1]北京市药品不良反应监测中心,北京100024

出　　处：《中国药物警戒》2004年第1期31-36,共6页Chinese Journal of Pharmacovigilance

基　　金：国家食品药品监督管理局药品评价中心2003年项目的部分内容

摘　　要：目的了解SARS流行期间与既往3年同期SARS预防用药不良反应(AdverseDrugReactions,ADR)情况。方法对北京市药品不良反应监测中心近4年收到的与胸腺肽、干扰素、利巴韦林和转移因子有关的ADR进行分析,并将SARS流行期间相应药物(包括中药)的ADR与既往3年同期进行比较。结果由于健康人群预防用药,SARS流行期间ADR报告数明显增多,ADR人群的年龄范围广,构成更趋年轻。SARS流行期间和既往同期预防用药的ADR均集中于用药后前3天。干扰素主要表现为流感样综合征,胸腺肽为过敏反应,中药为消化系统反应,也出现了一些罕见ADR。所有病例预后良好。结论在疗效不确定的情况下是否提倡大人群使用预防用药值得进一步商榷。Objective To investigate the adverse drug reactions (ADRs) associated with precautionary medication against SARS and that of the corresponding periods of last three years. Method Describe the reported ADRs associated with thymosin, interferon, transfer factor and ribavirin in recent 4 years. Meanwhile, ADRs of the 5 medicines (including traditional Chinese medicine) during SARS outbreak are compared with which in corresponding periods. Result The reported ADRs are significantly increased because of medicine preventions in healthy population during SARS outbreak. The main ADRs are flu-like symptoms, anaphylaxis and gastrointestinal disturbance in interferon, thymosin and traditional Chinese medicine respectively. These ADRs mainly occurred within initial 3 days in both periods. Despite of some rare ADRs, all cases are reversible. Conclusion It is suggested that careful consideration should be paid when almost whole population take precautionary medication confronting emergency like SARS.

关 键 词：SARS流行期间 预防用药 不良反应分析 药品不良反应监测中心 用药不良反应 流感样综合征 消化系统反应 ADR报告 Drug 转移因子 利巴韦林 健康人群 主要表现 过敏反应 胸腺肽 干扰素 同期 北京市 用药后 不确定 中药 

分 类 号：R563.1[医药卫生—呼吸系统] R978.1[医药卫生—内科学]