用Calyculin A诱导的PCC断片率检测甲状腺癌患者^(131)I治疗中染色体损伤程度  

STUDY ON THE CHROMOSOME DAMAGE IN PATIENTS TREATED WITH IODINE-131 FOR THYROID CARCINOMA USING PCC FRAGMENT RATES INDUCED BY CALYCULIN A

作　　者：朱巍[1] 郑斯英[1] 曹建平[1] 周献锋[1] 罗加林[1] 朱财英[1] 

机构地区：[1]苏州大学放射医学与公共卫生学院,215007

出　　处：《辐射防护》2005年第3期168-170,192,共4页Radiation Protection

基　　金：苏州大学医学发展基金重点项目(EE/26032)。

摘　　要：采用CalyculinA诱导的染色体凝聚断片率来检测甲状腺癌患者接受131I治疗过程中染色体损伤程度,并与常现法染色体双着丝粒体畸变率进行了比较研究。结果表明,CalyculinA法PCC断片率能更真实地反映131I治疗后患者染色体受损程度。The PCC fragment rates induced by Calyculin A was used to study the degree of chromosome damage during the radiotherapy using iodine-131 on thyroid carcinoma patients, and compared with conventional aberrations. The results showed that PCC fragment rates of induced by Calyculin A was more precise than general chromosome assay technique.

关 键 词：损伤程度 甲状腺癌 染色体 PCC 治疗 患者 断片 检测 诱导 比较研究 受损程度 畸变率 着丝粒 

分 类 号：R736.1[医药卫生—肿瘤]