结直肠癌的预后因素评估  

Evaluation of multiple prognostic factors in colorectalcancer

作　　者：王杉[1] 于永祥[1] 张嘉庆[1] 张清[1] 

机构地区：[1]北京医科大学人民医院外科,北京医科大学第一医院医学统计室

出　　处：《中华外科杂志》1994年第5期289-291,共3页Chinese Journal of Surgery

摘　　要：作者在对８３例结直肠癌患者临床随访和病理形态学观察的基础上，采用流式细胞分析技术、核仁组成区嗜银蛋白（ＡｇＮＯＲ）染色技术、ＡＢＣ法ｒａｓ癌基因产物ｐ２１￣（ｒａｓ）和癌胚抗原（ＣＥＡ）免疫组化染色的图象分析技术，分别测定ＤＩ、ＰＩ、ｐ２１Ｄ、ＡｇＮＯＲ和ＣＥＡ，并与六项临床病理指标结合进行多因素逐步判别分析。其中病理分期、组织学分级、ＤＩ、ｐ２１Ｄ和ＡｇＮＯＲ等六项指标被选入Ｆｉｓｈｅｒ判别函数，预测患者的预后，其效率、敏感性和特异性分别为９１．５７％，８７．１８％和９５．４５％。Abstract A multivariate stepwise discriminant analvsis wasperformed to evaluate the prognostic value of DI, PI,AgNOR, p21D, CEAD and several clinicopathologicalfeatures(age,sex,tumor location,hstological grad-ing, typing and staging)in 83 patients with colorectalcancer who underwent radical surgery。Afisher’ s dis-criminant function was established by using 6 selecteditems(staging,grading,DI,PI,AgNORand p21D)。It’ s efficiency,sensitivity and specificity were91.28%, 87.18%, and 95. 45%respectively, Correla-tive studies on DI,PI,AgNOR and p21D indicatedthat they are independent factors influencing progno-sis. Therefore,in addition to Dukes’ s classificationand histopathological grading of the tumor, thesemolecular biological factors can be considered as a newclue to evaluation of patients prognosis.

关 键 词：结肠肿瘤 直肠肿瘤 预后 癌 

分 类 号：R735.307[医药卫生—肿瘤]