锂增强小鼠LAK细胞活性及其体内抗瘤作用的研究  

THE ENHANCING EFFECT OF LITHIUM ON MOUSE LAK CELL ACTIVITY AND ITS ANTITUMOR ACTIVITY

作　　者：蔡冬坡[1] 吴易元[1] 

机构地区：[1]中国医学科学院肿瘤研究所免疫室

出　　处：《中华微生物学和免疫学杂志》1994年第1期37-40,共4页Chinese Journal of Microbiology and Immunology

摘　　要：本文观察了锂体外对小鼠ＬＡＫ细胞的作用及其体内抗瘤作用，以期找到一种能增强ＬＡＫ细胞活性，降低ＩＬ－２毒副作用的免疫调变剂。在ＩＬ－２诱导ＬＡＫ的同时加入ＬｉＣｌ，则能增强ＬＡＫ细胞的活性。以Ｃ５７ＢＬ／６小鼠接种Ｂ１６黑色素瘤细胞为荷瘤小鼠模型，比较了ＩＬ－２／ＬＡＫ，单独锂及ＩＬ－２／ＬＡＫ合并锂三组的抗瘤作用，结果表明，单独锂及ＩＬ－２／ＬＡＫ组与对照组相比均有抗瘤作用，但ＩＬ－２／ＬＡＫ和锂一起作用，其抗瘤作用最强，表现为能抑制肿瘤的生长及延长荷瘤小鼠的存活时间。因此，锂可望作为一种新型的免疫调节剂用于免疫性疾病及肿瘤的治疗。The in vitro effect of lithium on mouse lymphokine-activated killer cell(LAK)activity and its antitumor activ-ity in vivo were observed. LAK activity was enhanced when LiCl was added during LAK cell induction. By using amouse melanoma experimental model,the effect of lithium on tumor growth has been studied. Both lithium aloneand IL-2/LAK had antitumor effect, whereas the treatment of IL-2/LAK in combination with lithium had thestrongest inhibitory effect on tumor growth. This treatment resulted in reduction of tumor size and prolonged sur-vival of tumor-bearing mice compared with other treatment.Therefore,it is hopeful that lithium can be used as anew immunomodulator for cancer immunotherapy and immune diseases.

关 键 词：氯化锂 白细胞介素2 杀伤细胞 

分 类 号：R730.3[医药卫生—肿瘤]