胃原发癌和转移癌病理形态及FCM配对研究  

Comparative Pathological and FCM Studies on Primary Cancers and Their Corresponding Metastatic Cancers in Stomach

作　　者：张杰英[1] 张祥宏[1] 吕贵华[1] 陈文磊[1] 张玉敏[1] 赵文元[1] 王凤荣[1] 胡志彪[1] 张玉印[1] 王风安[1] 王学文[1] 

机构地区：[1]河北医学院第二医院,河北医学院卫生系

出　　处：《中华物理医学杂志》1994年第1期32-34,共3页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：以常规病理学观察和ＦＣＭ技术相结合的研究方法配对分析了３４例胃癌的原发癌和其。相应局部淋巴结转移癌的病理形态、分化程度、细胞ＤＮＡ含量和细胞增殖情况的变化。结果发现，尽管多数转移癌与其相应原发癌在上述诸方面基本一致，但有２９％病例转移癌的分化程度低于原发癌而另有１８％的病例则高于原发癌。在ＦＣＭ分析的２３个胃癌病例中，有４例原发癌细胞呈明显ＤＮＡ异倍体，但其相应转移癌细胞为ＤＮＡ二倍体或近二倍体；另２例转移癌细胞ＤＮＡ含量明显高于原发癌。细胞增殖指数亦可见类似变化。Pathological morphology, differentiation, cellular DNA contents and ecll proliferation index .were comparatively studied between the primary lesions and their corresponding metastatic lesions in 34 gastric carcinoma cases.The results revealed that although there were not much variations in pathological morphology, cellular DNA contents and PI between the primary lesions and their corresponding metastatic lesions in most of the gastric carcinoma cases, yet pathologically, differentiation of the metastatic carcinomas was lower than that of their corresponding primary counterparts in 29% of the cases and higher than the latter in 18% of the cases. FCM results showed that among the 23 cases analyzed, cellular DNA contents of metastatic lesions were lower than that of their corresponding primary tumors in 4 cases. with the primary tumors showing dramatic DNA aneuploidy while the metastatic tumors showing DNA diploidy or near diploidy changes, contrary changes were found in other 2 cases. both showing DNA aneuploidy. Cell proliferation index also showed similar changes.

关 键 词：转移 分化 流式细胞光度 胃肿瘤 

分 类 号：R735.202[医药卫生—肿瘤]