结肠黑变病的病理探讨  

PATHOLOGICAL INVESTIGATION OF MEL ANOSIS COLI

作　　者：纪小龙[1] 朱成[1] 李向红[1] 张子其[1] 张勇[1] 李维华[1] 王孟薇[1] 

机构地区：[1]中国人民解放军总医院

出　　处：《中华消化杂志》1994年第1期38-40,共3页Chinese Journal of Digestion

摘　　要：结肠黑变病国外文献报道较多，国内文献很少。我们收集解放军总医院１９８５～１９９０年２２８３例纤维结肠镜检查中发现的黑色病变并取活检经病理证实的１３４例进行临床病理分析，主要对其中２２例进行超微结构观察。结果发现结肠黑变病是一种较常见的大肠病变，与便秘和服用泻药关系不密切。电镜观察见纤维母细胞亦有吞噬色素的现象等。说明对中国人的大肠黑变病有必要进行深入的研究。34 cases of melanosis coli(5.9%)were diagnosed histologically among colonoscopies in 2283cases.20 cases of melanosis coli had no history of constipation(15%).Ultrastructural study in 22cases showed three morphological features that have not been reported in literature: increasingnumbers of endocrine cells in mucosa,rough dense granules appeasing in mitochondria ofepithelial cells;and phagocytosis of pigment by fibroblasts.These results show that the melanosiscoli is not uncommon colonoscopic findings in Chinese patients and there is close relationshipbetween laxatives and melanosis coli.The mechanism of deposited pigment would be furtherinvestigated.

关 键 词：结肠黑变病 超微结构 吞噬 病理学 

分 类 号：R574.620.2[医药卫生—消化系统]