肝硬化患者胃、十二指肠粘膜六种胃肠激素含量变化及其临床意义  

CONTENTS OF SIX GASTROINTESTINAL HORMONES IN GASTRIC ANDDUODENALMDc0SAANDTHEIE810NIFICANCE INPATIENTSWITHHEPATIC CIBBHOSIS

作　　者：陈仕珠 张忠兵[1] 王效民 刘金燕 程秀兰[1] 张洪博[1] 胡家露[1] 

机构地区：[1]空军西安医院,第四军医大学西京医院

出　　处：《中华消化杂志》1994年第2期74-77,共4页Chinese Journal of Digestion

摘　　要：本文研究了肝硬化（ＨＣ）患者胃、十二指肠粘膜６种胃肠激素含量变化及其意义。结果表明，肝硬化患者胃粘膜血管活性肠肽（ＶＩＰ）含量明显增加（Ｐ＜０．０５）；胃动素明显降低（Ｐ＜０．０１）。十二指肠（Ｄ）、粘膜生长抑素（ＳＳ）、脑啡肽含量明显减少（Ｐ＜０．００５）；血管加压素β－内啡肽（β－ＥＰ）明显增加（Ｐ＜０．０５）、ＶＩＰ含量与胃、Ｄ粘膜充血程度呈正相关（Ｐ＜０５），与有、无腹水及其程度关系不密切（Ｐ＞０．１），与食道静脉曲张程度有一定联系，但不显著（Ｐ＝０．１）。胃粘膜β－ＥＰ、Ｄ粘膜ＳＳ含量随肝功能下降而递增（Ｐ＜０．０５）。提示ＨＣ患者充血性胃肠粘膜病变及消化不良等可能与粘膜胃肠激素含量异常有关。n this paper,the contents of six gastrointestinal hormones in gastric and duodenalmucosa and their significance in patients with hepatic cirrhosis were discussed. The resultsshowed that the content of vasoactive intestinal peptide(VIP) was markedly increased (P<0.025),while motilin significantly decreased(P<0.01)in gastric mucosa. The contents osomatostatin(SS)and met-enkephalin were significantly decreased (P<0.005),and those carg-vasopressin and β-endorphin(β-EM) markedly increased(P<0.05)in duodenal mucosa.positive correlation was found between the content of VIP and the degree(Ⅰ-Ⅲ)of congestionof gastric and duodenal mucosa(P<0.025);no remarkable correlation with varying degrees ofascites. The results suggest that gastroduodenal mucosal congestion and dyspepsia in patientswith hepatic cirrhosis may be associated with abnormal contents of gastrointestinalhormones in the mucosa.

关 键 词：胃肠激素 胃肠粘膜 肝硬变 

分 类 号：R575.2[医药卫生—消化系统]