男性慢性肝病患者下丘脑－垂体－性腺轴功能的研究  

THE STUDY ON HYPOTHALAMIC-PITUITARY-GONADAL FUNCTION IN MEN WITH CHR0NIC LIVER DISEASE

作　　者：李运泽[1] 傅宝玉[1] 姜若兰[1] 

机构地区：[1]中国医科大学第一医院消化科

出　　处：《中华消化杂志》1994年第6期336-338,共3页Chinese Journal of Digestion

摘　　要：用放射免疫法检测６１例男性慢性肝病患者血清睾酮（Ｔ）、雌二醇（Ｅ２）、泌乳素（ＰＲＬ）、促黄体生成素（ＬＨ）和卵泡刺激素（ＦＳＨ）的浓度，并对部分病例进行促黄体生成素释放激素（ＬＲＨ）垂体兴奋试验和绒毛膜促性腺激素（ＨＣＧ）刺激试验。结果示，肝硬化基础血清Ｔ显著降低（Ｐ＜０．０１）；对ＬＲＨ垂体兴奋试验ＬＨ多数呈正常反应，部分呈延迟反应或低反应；而对ＨＣＧ刺激试验均呈正常反应。提示肝硬化患者有下丘脑－垂体－性腺轴功能障碍。In the present study,serum concentrations of testosterone(T),estradiol(E2),prolactin(PRL),luteinizing hormone(LH)and follicule-stimulating hormone(FSH)were measured in 6l men withchronic liver disease using RIA. Some of them underwent luteinizing hormone releasinghormone(LRH) pituitary exciting test and chorionic gonadotropin(HCG)stimulating test.Theresults showed that in patients with posthepatic cirrhosis,serum concentrations of T Weresignificantly decreased (P<0.01),those of E2 normal or decreased,and those of LH and FSH werenormal.The HCG stimutation test showed a normal response.To LRH pituitary exciting test,mostof the patients expressed a normal response,but some showed a delayed or low response.Theresults suggest that there is hypothalamic-pituitary-gonadal dysfunction in the patients withcirrhosis mainly at the level of hypothalamus. In a few patients,the dysfunction maybe at bothhypothalamus and pituitary. Hypoorchidia is secondary.

关 键 词：肝疾病 睾酮 雌二醇 泌乳素 促黄体生成素 男性 

分 类 号：R575.02[医药卫生—消化系统]