c-myc基因与胆管癌关系的研究  

Overexpression and significance of c-myc gene in biliary tract cancer

作　　者：王耀辉 孔凡民[1] 佟玉兰[1] 

机构地区：[1]中国医科大学附属第一医院外科

出　　处：《中国医科大学学报》2005年第3期248-248,252,共2页Journal of China Medical University

摘　　要：目的:探讨c myc基因与胆管癌的关系。方法:原位杂交方法检测c mycmRNA在30例胆管癌中的表达,同期胰头癌切除之胆管10例做正常对照。结果:c mycmRNA在胆管癌中的表达率为53.3%,对照组中无表达,差异极显著(P<0.01)。c mycmRNA阳性率与胆管癌细胞分化程度、原发癌的浸润程度、淋巴结转移有关。结论:c myc基因与胆管癌的发生、发展密切相关,有望成为与胆管癌有关的一项生物学指标。Objective: To study the relation between c-myc gene and biliary tract cancer. Methods:We determined the expression of c-myc gene in 30 cases of biliary tract cancer by using in situ hybridizations. Ten sections of normal biliary tract was used as control.Results:The positive rate of overexpression of c-myc gene in biliary tract cancer was 53.3%,and no expression was found in the 10 cases of normal biliary tract(P<0.01).The positive rate of overexpression of c-myc gene was related to the degree of cell differentiation, the invading degree of primary cancer, the transfer of lymph node. Conclusion:The overexpression of c-myc gene was related to the pathogenesis and development of biliary tract cancer. It may become an important biological index about biliary tract cancer.

关 键 词：癌基因 超表达 杂交 胆管癌 

分 类 号：R735.8[医药卫生—肿瘤]