交替半身照射清除大鼠体内残留白血病细胞作用的研究  

STUDY ON THE EFFECT OF ELlMlNATlON OF RESlDUALLEUKEMlC CELLS lN VlVO BY ALTERNATlVE HEMl-BODY IRRADlATlON

作　　者：褚建新[1] 赵钧铭[1] 应红光[1] 王淑萍[1] 姜露[1] 王敏[1] 宋世均 王玉珂 马元俊[1] 常力方[1] 

机构地区：[1]中国医学科学院协和医科大学血液学研究所,中国医学科学院协和医科大学放射医学研究所,天津医学院附属医院放射科

出　　处：《中华血液学杂志》1994年第5期236-238,共3页Chinese Journal of Hematology

基　　金：卫生部科学研究基金

摘　　要：为了进一步提高交替半身照射（ＨＢＩ）清除体内残留白血病细胞的作用，本研究用大鼠ＢＮＭＬ白血病的亲代细胞进行了实验，进一步证实环磷酰胺（ＣＴＸ）加交替ＨＢＩ治疗，不仅可不用骨髓移植即能重建造血而且能延长生存时间，部分大鼠获得治愈。同时，还探讨了不同的ＣＴＸ＋交替ＨＢＩ治疗方案对疗效的影响，证明交替ＨＢＩ的疗效与化疗预处理的效果、开始照射的时间以及两次照射间隔时间有密切的关系，提出了最佳治疗方案，为该治疗方案用于临床提供了实验依据。or further enhancing the effect of elimination of mi-nimal residual leukemia by alternative hemi-body irradia-tion(HBI),this study was completed on parent cell lineof BNML model.The results showed that the treatmentof″CTX+alternative HBI″not only could reconstructhemopoiesis without bone marrow transplantation, butalso made the animals survive longer time and some ofthem be cured. Otherwise, the factors of influence ofcurative effects of the different designs of″CTX+alter-native HBI″were investigated.The results showed thatthe curative effects were closely related to the effect ofthe precondition,the time to start irradiation and theinterval between two irradiations.A best design of″CTX+alternative HBI″have been proposed.Thisstudy provides an experimental evidence for using thenew strategy in clinic.

关 键 词：白血病 交替半身照射 疾病模型 

分 类 号：R733.705[医药卫生—肿瘤]