单克隆抗体HIP_2对人CFU－GM及CFU－AML体外作用的研究  

STUDY ON THE ROLE OF MoAb-HIP_2 lN GRANULOCYTE-MACROPHAGE PROGENlTORS AND ACUTE MYELOlDLEUKEMlA PROGENlTORS lN VlTRO

作　　者：施红 严文伟 韩俊领 邱录贵 

机构地区：[1]中国医学科学院协和医科大学血液病医院

出　　处：《中华血液学杂志》1994年第5期245-247,共3页Chinese Journal of Hematology

摘　　要：刺激型抗人血小板单克隆抗体──ＨＩＰ_２在体外有刺激人造血祖细胞集落形成的作用。本研究结果显示：ＨＩＰ_２对正常人和急性髓系白血病（ＡＭＬ）初诊及缓解患者的粒单系造血祖细胞（ＣＦＵ－ＧＭ）集落产率有明显刺激作用，而对ＡＭＬ祖细胞（ＣＦＵ－ＡＭＬ）集落产率无明显刺激作用，为临床ＡＭＬ患者在化疗抑制期及骨髓移植造血抑制期用该抗体加速造血恢复提供了实验依据。cAb HIP_2 had been shown to stimulate colony for-mation of hematopoietic progenitors in vitro.Our resultsindicated that HIP_2 significantly stimulated granulocyte-macrophage progenitors colony formation in normal indi-viduals;acute myeloid leukemia(AML)patients at di-agnosis and in complete remission,but rarely stimulatedthe growth of AML progenitors.The data implied thatHIP_2 could be used to accelerate the recovery ofhematopoiesis during myelogenic aplasia afterchemotherapy and bone marrow transplantation.

关 键 词：白血病祖细胞 白血病 单克隆抗体 

分 类 号：R733.7[医药卫生—肿瘤]