从AML细胞表面标记特点看AML、ALL鉴别时髓系单抗的选择  

CORRECT SELECTlON OF ANTI-MYELOlD CELLMONOCLONAL ANTIBODIES iN THE DISCRIMINATIONOF AML FROM ALL ON IMMUNOPHENOTYPICCHARACTERISTICS

作　　者：汤美华[1] 周宇[1] 沈德诚[1] 卞寿庚[1] 钱林生[1] 王琦[1] 王志澄[1] 陈璋[1] 

机构地区：[1]中国医学科学院血液学研究所,天津市儿童医院

出　　处：《中华血液学杂志》1994年第9期466-468,共3页Chinese Journal of Hematology

摘　　要：应用一组单克隆抗体（单抗），采用免疫荧光法分析了２１８例急性髓系细胞白血病（ＡＭＬ）患者细胞的免疫表型。结果提示ＣＤ＿（３３）、ＣＤ＿（１３）和ＣＤ＿（１５）为ＡＭＬ的主要标记；免疫分型在一定程度上有助于ＡＭＬ各亚型的鉴别。强调指出：在ＡＭＬ和急性淋巴细胞白血病（ＡＬＬ）鉴别时，ＣＤ＿（３３）、ＣＤ＿（１３）和ＣＤ＿（１５）应联合应用。配以胞浆抗原的检测，将是ＡＭＬ和ＡＬＬ鉴别时行之有效的髓系单抗选择方案。he immunophenotypes of 218 cases of acute myeloidleukemia (AML) were analysed with a panel of mono-clonal antibodies by immunofluorescent method. The re-sults showed that: 1. 65%, 63% and 47% of patientswere and CD respectively , which are majorcell surface markers of AML; 2. immunophenotypingmay be helpful for distinguishing subtypes of AML; 3.CD_(33),CD_(13) and CD_(15) must be used in combination in thedifferentiation of AML from ALL. Detection of cyto-plasmic antigen is very useful for the diagnosis of CDCD , CD AML.

关 键 词：白血病 单克隆抗体 免疫分型 诊断 

分 类 号：R733.710.4[医药卫生—肿瘤]