自体骨髓移植治疗小儿恶性肿瘤  

CLINCAL APPLICATION OF AUTOLOGOUS BONE MARROW TRANSPLANTATION IN THE TREATMENT OF CHILDREN WITH VARIOUS MALIGNACIES

作　　者：王耀平[1] 汤静燕[1] 应大明[1] 沈玉诚 

机构地区：[1]上海市儿科医学研究所,上海第二医科大学附属新华医院

出　　处：《中华血液学杂志》1994年第10期508-510,共3页Chinese Journal of Hematology

摘　　要：报道本院１９８０～１９９３年２月因患各种恶性肿瘤４４例患儿接受自体骨髓移植治疗的疗效。其中恶性脑部肿瘤３７例，恶性淋巴瘤３例，神经母细胞瘤２例，急性淋巴细胞白血病ＣＲ＿１２例。资料提示：①自体骨髓移植是治疗小儿恶性脑部肿瘤的有效方法之一，但移植后仍需继续接受维持治疗３年。②恶性淋巴瘤、晚期神经母细胞瘤和急性白血病，应在综合治疗、达完全缓解后移植。③骨髓移植后ＣＭ－ＣＳＦ对促进中性粒细胞恢复起重要作用。④自体骨髓移植是一种较安全、有效、费用较省的治疗方法，值得推广应用。orty four children with various malignancies received autologous bone marrow transplantation(ABMT)from 1980 to Feb.1993 in our hospital.Among them,37 had different types of malignant brain tumors,3 ad- vanced non-Hedgkin' s lymphoma,2 neuroblastoma atIV stage and 2 acute lymphoblastic leukemia in CR_1.The results indicated that①ABMT was one of the mosteffective methods in the treatment of childhood malig-nant brain tumors,but the patient should receive furthermaintenance chemotherapy for 3 years after ABMT.②children with malignant lymphomas, advanced neurob-lastoma and acute leukemias should first receive combi-nation chemotherapy to achieve complete remission be-fore undergoing ABMT. ③if the absolute neutrophilcount delayed to recover after ABMT,GM-CSF shouldbused to promote the recovery and④ABMT was asafe,effective and less expensive method in the treat-ment of children with advanced malignancies.

关 键 词：肿瘤 骨髓移植 自体 儿童 癌 免疫疗法 

分 类 号：R730.51[医药卫生—肿瘤]