维甲酸治疗急性早幼粒细胞白血病患者血清G－CSF水平的变化与意义  

STUDY ON VARIATION OF SERUM G-CSF LEVEL INACUTE PROMYELOCYTIC LEUKEMIA TREATED WITHALL-TRANS RETINOIC ACID

作　　者：姜国胜[1] 孙关林[1] 吴文[1] 周荣富[1] 李秀松[1] 沈志祥[1] 张芬琴[1] 陈珏[1] 王振义[1] 

机构地区：[1]上海第二医科大学附属瑞金医院,上海血液学研究所细胞生物学研究室,山东省医学科学院

出　　处：《中华血液学杂志》1994年第11期585-587,共3页Chinese Journal of Hematology

基　　金：国家自然科学;八五攻关基金

摘　　要：用酶联免疫吸附试验（ＥＬＩＳＡ）法检测了３５例急性早幼粒细胞白血病（ＡＰＬ）患者治疗前血清粒系集落刺激因子（Ｇ－ＣＳＦ）水平，其中２５例作全反式维甲酸（ＡＴＲＡ）治疗后的动态观察。结果表明ＡＰＬ患者治疗前血清Ｇ－ＣＳＦ检出率为１１．４３％（４／３５），１８例正常人对照均未能检出Ｇ－ＣＳＦ。２５例ＡＰＬ患者ＡＴＲＡ治疗后第６天血清Ｇ－ＣＳＦ检出率即明显升高，直至１２天（Ｐ＜０．０５），１５天后逐渐下降。外周血ＷＢＣ出现高峰时血清Ｇ－ＣＳＦ的检出率高达８３．３３％（１５／１８）。Ｓｐｅａｒｍａｎ等级相关分析血清Ｇ－ＣＳＦ水平与外周血ＷＢＣ、早幼粒或中幼以后粒系细胞绝对数呈相关性（Ｐ均＜０．０５）。并初步分析了血清Ｇ－ＣＳＦ变化的意义。AbstractThe level of serum G-CSF in patients with acutepromyelocytic leukemia (APL) was assayed by ELISAmethod. The results showed that the level of G-CSF in-creased in 11. 43% (4/35) of APL patients (equal to ormore than 0. 095ng/ml) prior to treatment, in all of 18normal controls, serum G-CSF was not detected. In 25APL patients treated with all-trans retinoic acid(ATRA), the serum G-CSF level increment startedfrom 6th day to 12th day and then gradually declined.Spearrnan's rank correlation analysis showed that serumG-CSF level was statistically related to the WBC (r=0. 275, P<0. 05), promyelocytes (r=0. 247, P<0. 05) or more mature granulocytes (r=0. 2055, P<0. 05).Key werde Serum G-CSF All-trans retinoic acidDifferentiation induction

关 键 词：粒细胞 白血病 集落刺激因子 维甲酸 药物疗法 

分 类 号：R733.730.5[医药卫生—肿瘤]