青少年健康人群白喉抗体水平调查分析  

An Investigation on the Level of Antibodies against Diphtheria in Teen-age People

作　　者：李国立[1] 方奎明 何华先 李业平 

机构地区：[1]湖南理工学院西院卫生科,湖南岳阳414000 [2]岳阳市卫生局 [3]岳阳市疾控中心

出　　处：《疾病监测》2005年第5期249-250,共2页Disease Surveillance

摘　　要：目的　了解青少年人群抗白喉抗体水平,为预防控制白喉提供依据。方法　采用随机抽样方法抽取调查点和被测人群,用间接血凝试验(IHA)检测抗白喉毒素抗体,结果分析采用χ2 检验和F检验。结果　青少年健康人群白喉抗体阳性率为80 .32 % (15 1/188) ,平均抗体滴度(GMT)为1∶12 .2 2 36 ,抗毒素平均含量(ATC)为0 .0 5 9IU/ml。抗体水平比较分析,年龄组中最高者是9～11岁组(96 .6 7% ) ,最低者是12～14岁组(48.78% ) ;城关(95 .4 5 % )高于农村(72 .13% ) ;男女性别间无差异。结论　岳阳市健康青少年人群的抗白喉抗体水平较高,能够有效防止白喉流行。Objective The target of this analysis was to investigate the level of antibodies against diphtheria in teen-age people, for providing the foundation of diphtheria control and prevention. Methods The investigation site and the samples from teen-age people were selected with random sampling. By means of indirect hemagglutination assay (IHA) the antibodies against diphtheria toxoid were examined. The results were analyzed with statistics methods, including χ 2 test and F test. Results Of 188 sera from 151 (80.32%) had a significant antbody titer against diphtheria toxoid, in which the geometric mean titer (GMT) was 1/12.2236. In the positive rates of different groups, the most was in 9-11 age group (96.67%), the lowest was in 12-14 age group (48.78%); it was higher in the town than in the countries; and it was no different between males and female. Conclusion The level of antibodies against diphtheriae in teen-age people in our city was high enough to prevent diphtheria epidemic.

关 键 词：白喉杆菌 抗体水平 青少年 预防 间接血凝试验 白喉 

分 类 号：R181.3[医药卫生—流行病学]