山刺玫果降血脂、抗氧化及保护血管内皮功能的实验研究  

Effects of Rosa davurica Pall Fruit on Reducing Blood Lipid,Anti-oxidation and Protection of Vascular Endothelium

作　　者：焦淑萍 [1] 杨春玫 [1] 初秋 [1] 姜虹 [1] 高维明 [2] 

机构地区：[1]北华大学,医学院,吉林,吉林,132013 [2]辽东学院,医学院,辽宁,丹东,118002

出　　处：《北华大学学报（自然科学版）》2005年第3期228-230,共3页Journal of Beihua University（Natural Science）

基　　金：吉林市科技发展计划项目(2002.300)

摘　　要：目的研究野生山刺玫果对高脂大鼠血脂代谢的影响、抗氧化及保护血管内皮功能的作用.方法观察不同剂量山刺玫果对高脂大鼠血清TC,TG,HDLC,SOD,GSH-Px,NO和内皮素(ET)的影响,以及对血清、肝脏、大脑组织MDA的影响.结果山刺玫果(4.0 g/kg)可显著降低高脂大鼠血清TC,TG,ET含量(P<0.01),并明显提高HDLC,NO含量(P<0.01);1.0 g/kg山刺玫果可明显降低血清及肝脏MDA含量(P<0.05),2.0 g/kg剂量可明显提高SOD,GSH-Px活性(P<0.05),以上给药时间56 d.结论山刺玫果具有显著降血脂、抗氧化、保护血管内皮细胞的作用,具有防治动脉硬化作用.ObjectiveTo study the effect of Rosa davurica pall fruit on blood lipid metabolism, antioxidation and protection of vascular endothelium in hyperlipidemia rat.MethodsEffects of different concentrations of the Rosa davurica pall fruit on the serum total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDLC)were tested in hyperlipidemia rat.so the serum superoxide dismutase(SOD), glutathione peroxidase(GSH-Px), NO, endothelin(ET) were tested. The malonaldehyde(MDA) in serum and liver were tested.ResultsThe serum TC, TG, ET in the Rosa davurica pall fruit model groups were obviously lower than that of the hyperlipidemia model group(P<(0.01)). While the HDLC, NO was much higher(P<(0.01)). The MDA in the (1.0 g)/(kg·d)×(56 d) dose were lower(P<(0.05)). While the SOD and GSH-Px in the (2.0 g)/(kg·d)×(56 d) dose was higher(P<(0.05)).ConclusionThe Rosa davurica pall Rosa fruit had the function of reducing blood lipid, anti-oxidation and protection of vascular endothelium. It had prevention of arteriosclerosis.

关 键 词：山刺玫果 降血脂 抗氧化作用 血管内皮细胞 

分 类 号：R965.2[医药卫生—药理学]