轻度认知障碍^(18)F-FDG PET显像的研究进展  

Progressing on ^(18) F-FDG PET Imaging in Mild Cognitive Impairment

作　　者：董孟杰[1] 林祥通[1] 赵军[1] 

机构地区：[1]复旦大学附属华山医院核医学科,200040

出　　处：《中国临床神经科学》2005年第2期209-212,217,共5页Chinese Journal of Clinical Neurosciences

摘　　要：轻度认知障碍(MCI)的病理改变与早期或临床前期阿尔茨海默病(AD)相似,MCI患者已经成为预测AD是否发生、有效延缓或早期干预治疗AD的最适群体,FDGPET脑功能显像可反映局部脑内葡萄糖代谢率,为MCI的病理学研究及临床诊断提供一种新的可靠工具。正确认识MCI与正常脑老化、AD脑葡萄糖代谢的不同、FDGPET图像特征及影响因素、对于预测病程及早期干预治疗、检测治疗效果、预防AD的发生及提高老年人生活质量有着重要的意义。There are similar pathological changes between mild cognitive impairment(MCI)and the patients with MCI have been the most suitable group to predict if Alzheimer's disease (AD) will develop,to delay the progressing of AD and to conduct interventive treatment.The functional imaging of FDG PET is very sensitive to detect the regional cerebral metabolic rate of glucose (rMRglu) and provide a reliable tool to study or to diagnose MCI.Realizing the differences of rMRglu and affecting factors among normal aging ,AD and MCI are of significant meanings to predict the course of AD,to text the curative effect ,to conduct early interventive treatment and even to improve the living standards of the aging.

关 键 词：^18F-FDG PET显像 轻度认知障碍(MCI) 早期干预治疗 阿尔茨海默病 葡萄糖代谢率 脑葡萄糖代谢 FDGPET 脑功能显像 病理学研究 正常脑老化 临床前期 病理改变 临床诊断 图像特征 治疗效果 生活质量 AD 老年人 预测 

分 类 号：R730.44[医药卫生—肿瘤] R734.2[医药卫生—临床医学]