102例白血病患者超氧化物歧化酶（SOD）活性和含量的相关性研究  

STUDY ON CORRELATION AND CLINICAL SIGNIFICANCE OF SUPEROXIDE DISMUTASE(SOD)ACTIVITY AND CONTENT IN 102 PATIENTS WITH LEUKEMIA

作　　者：朱传升[1] 张春原[1] 翁维权[1] 

机构地区：[1]青岛医学院附属医院内科,山东省千佛山医院内科

出　　处：《中华肿瘤杂志》1994年第1期39-42,共4页Chinese Journal of Oncology

摘　　要：我们测定了１０２例白血病患者血清超氧化物歧化酶（ＳＯＤ）的活性及全血Ｃｕ／ＺｎＳＯＤ的含量，并对其相关性进行了研究。显示急性白血病发病期，总ＳＯＤ活性及Ｃｕ／ＺｎＳＯＤ活性与含量皆明显降低，缓解期恢复正常，与其外周血血红蛋白值及白细胞数呈正相关，复发及死亡患者又下降。慢性粒细胞白血病患者Ｃｕ／ＺｎＳＯＤ活性与含量呈分离现象。慢性淋巴细胞白血病与正常人无差异。提示ＳＯＤ在白血病发生发展过程中起重要保护作用，检测ＳＯＤ水平可作为观察病情变化的指标，也有助于本病的分类及预后估计。Abstract Serum superoxide dismutase(SOD)activity and blood Cu/Zn SOD content were examined in 102cases of leukemia.The results showed that the total SOD activities,Cu/Zn SOD activities and contentsdeclined significantly in blast phase of acute leukemia,yet increased to normal levels in remission.There was a positive correlation between SOD and blood hemoglobin concentration as well as leucocytecount. It declinde again when leudemia recurred and in dying patients.There was a dissociation betweenCu/Zn SOD activities and contents in patients with chronic granulocytic leukemia.In chroniclymphocytic leukemia,both activity and contents of SOD were normal .It was suggested that SOD playsa protective role during the occurrence and development of leukemia.SOD is a useful parameter in thedifferential diagnosis of leukemias and monitoring clinical course of leukemias.

关 键 词：白血病 超氧化物歧化酶 

分 类 号：R733.7[医药卫生—肿瘤]