102例胃肠道平滑肌肿瘤的研究─—组织学、免疫组化及AgNOR分析  

HISTOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY AND AgNOR ANALYSIS OF SMOOTH MUSCLE TUMORS OF THE DIGESTIVE TRACT

作　　者：汪筱娟[1] 唐卫华[1] 于佩良[1] 苏晓萍[1] 李素英[1] 

机构地区：[1]山东医科大学病理教研室

出　　处：《中华肿瘤杂志》1994年第2期128-131,共4页Chinese Journal of Oncology

摘　　要：１０２例胃肠道平滑肌肿瘤中，平滑肌瘤（ＬＭ）４９例，平滑肌肉瘤（ＬＳ）５１例，平滑肌母细胞瘤（ＬＢ）２例。肿瘤大小ＬＭ平均３．７ｃｍ，ＬＳ平均７．４ｃｍ。ＬＭ无核分裂象，ＬＳ核分裂象均≥１个／１０ＨＰＦ，过半数的ＬＳ可见到边缘侵犯、瘤巨细胞及幼稚瘤细胞，ＡｇＮＯＲ平均含量，在ＬＭ与ＬＳ之间，差异有极显著性意义；在生存组与死亡组之间，差异亦有显著性意义。但ＡｇＮＯＲ数目与肿瘤体积、核分裂数及病人的生存期限无直线相关关系。波状蛋白和纤连蛋白阳性率为１００％，骼蛋白阳性率为５２％，细胞角蛋白全部阴性，Ｓ－１００（＋）６例，其中２例Ｄｅｓ亦呈（＋）。随访７１例，ＬＭ获访２９例，除２例死于其他疾病外全部存活；ＬＳ获访２４例，死亡１５例，其中３例原诊断为ＬＭ。Abstract Smooth muscle tumors of the esophagus(n=29),stomach(n=30),small intestine (n=31)andlarge intestine (n=12)were examined histologically and immunohistochemically for vimentin(Vim),desmin(Des), S100,fibronectin (FN)and cytokeratin(Cyt)and for nucleolar organizer regions(AgNOR).There were 49 cases of leiomyoma(LM),51 cases of leiomyosarcoma (LS)and 2 cases of leiomyoblastoma (LB).Histologically,LS was characterized by cellular atypia,more cells in mitosis and imvasion to adjacent normal tissue .No mitotic figure was observed in LM.AgNOR was more abundantin number in LS than LM(P<0.00,)but it had no direct relation to tumor size ,number of cells in mitosis and patients’survival period.Immunohistochemical studies of Vim,Des,S100,FN and Cyt re-vealed that none of them was very helpful in the differential diagnosis of LM from LS.

关 键 词：肠肿瘤 平滑肌瘤 病理 胃肿瘤 

分 类 号：R735.2[医药卫生—肿瘤]