基因重组人粒细胞集落刺激因子对肿瘤化疗所致白细胞减少的临床疗效观察  

CLINICAL STUDY OF RECOMBINANT HUMAN GRANULOCYTE COLONY STIMULATING FACTOR(rhG-CSF)LEUKOPENIA INDUCED BY CHEMOTHERAPY IN CANCER PATIENTS

作　　者：石远凯[1] 周际昌[1] 冯奉仪[1] 曾万勇[1] 李青[1] 何小慧[1] 张弘刚[1] 张湘茹[1] 周立强[1] 

机构地区：[1]中国协和医科大学中国医学科学院肿瘤医院内科

出　　处：《中华肿瘤杂志》1994年第3期207-210,共4页Chinese Journal of Oncology

摘　　要：研究观察了基因重组人粒细胞集落刺激因子（ｒｈＧ—ＣＳＦ）对恶性淋巴瘤、肺癌及乳腺癌化疗后，白细胞和中性粒细胞减少的防治作用。化疗过程中，白细胞降至４．０×１０９／Ｌ以下时入组，并做为对照周期。其后的化疗周期化疗药物未次给药结束后４８小时起，皮下注射ｒｈＧ—ＣＳＦ（７５μｇ·次·天－１）。结果表明，ｒｈＧ—ＣＳＦ可以明显减轻化疗过程中白细胞下降的程度、缩短白细胞在４．０×１０机以下的持续时间及恢复到４．０×１０９／Ｌ以上的时间。ｒｈＧ—ＣＳＦ对中性粒细胞的作用与白细胞相似，其毒副反应轻微，安全可靠。Abstract The clinical usefulness of Recombinant Human Granulocyte Colony Stimulating Factor(rhG-CSF,Filgrastim,GRAN) was evaluated in patients with leukopenia and neutropenia followingchemotherapy for non-Hodgkin’s lymphoma, lung cancer and breast cancer. Duringchemotherapy when patients’leukocyte count(WBC)fell below 4.0 ×109/L,rhG-CSF(GRAN)at a dose of 75μg/body·day was given subcutaneously 48 hours after the termination of chemotherapy. The results indicated that rhG-CSF(GRAN)could elevate nadirs of WBC and significantly shor-tened leukopenic period with WBC below 4.0×109/L and expedited the recovery of WBC to levelsabove 40×109/L。The response of granulocytes rhG-CSF(GRAN)was similar to that of WBC.rhG- CSF(GRAN)’s side eflects were mild.

关 键 词：粒细胞 集落刺激因子 白细胞减少 

分 类 号：R730.5[医药卫生—肿瘤]