下肢骨肉瘤区域高温隔离灌注化疗方法学的探讨  

ON THE METHOD OF HYPERTHERMIC CHEMOTHERAPY BY REGIONAL ISOLATED PERFUSION FOR TUMORS OF LOWER EXTREMITIES

作　　者：徐世伟[1] 陈芳[1] 赵玉华[1] 

机构地区：[1]浙江医科大学附属第二医院胸心外科

出　　处：《中华肿瘤杂志》1994年第4期310-313,共4页Chinese Journal of Oncology

摘　　要：总结了１９９０年８月～１９９３年７月共３０例下肢骨肉瘤区域高温隔离灌注化疗病人，男１９例、女１１例，年龄平均２１岁。肿瘤部位：股骨下端２０例、胫骨上端９例、腓骨１例。隔离灌注化疗６０分钟，肿瘤缘深部组织温度保持在４２℃。结果：全部患者灌注后局部肿胀明显减退，肿块收缩，质地变硬。二周内患肢周径减少，关节活动度增加。病理检查，瘤体坏死率达９０％～９５％。引起并发症为２例骨筋膜综合征，１例急性肾衰。作者认为，这是一项有效的治疗手段。Abstract From August 1990 to June 1993, 30 patients with osteosarcoma of lower extremities weretreated with chemotherapy by hyperthermic regional isolated perfusion. There were 19 male and 11female with a mean age of 21(15～28) years. All of the tumors were located in the lower limbs:20 on the femora, 9 on the tibiae and 1 on the fibula。Chemotherdpy was going on for 60munithe during hyperthermic regional isolated perfusion. Temperature was kept at 42℃ in deepsoft tissue around the tumor during perfusion. The asults showed that local edema of the limbsWere reduced observably,tumors were shrunken and hardened after perfusion。 Perimeter of the limbswere decreased and mobility of the limbs increased. Pathological examination indicated that all ofthe tumors responded well to the chemothefapy by perfusion and 90%～95 % of the osteosarcomacells were destroyed. Two cases were complicated with compression syndrome,and 1 with renal fail-ure。The authors would suggest that hyperthermic regional isolated perfusion is an effectivechemotherapeutic method in management of malignant tumors of limbs.

关 键 词：骨肿瘤 药物疗法 肉瘤 灌注疗法 

分 类 号：R738.105[医药卫生—肿瘤]