60℃碘油栓塞兔VX_2肝癌  

Embolism of Hepatocarcinoma with Heated Lipiodol via Hepatic Artery in VX_2 Rabbits Model

作　　者：曹玮[1] 张洪新[1] 王执民[1] 刘毅勇[1] 李文献[1] 

机构地区：[1]第四军医大学唐都医院介入科,陕西西安710038

出　　处：《实用放射学杂志》2005年第6期561-563,共3页Journal of Practical Radiology

基　　金：全军青年基金(01Q124);第四军医大学科技创新工程(CX99A016)资助。

摘　　要：目的评价60°C碘油栓塞对兔VX2肝癌的抑瘤效果。方法将VX2瘤细胞接种于30只新西兰白兔肝左叶,建立兔肝癌模型,随机分3组,每组10只。经导管向肝动脉分别注入生理盐水、37°C碘油、60°C碘油,1周后观察各组肿瘤体积及血清AST水平,以及瘤兔的存活期。结果60°C碘油组生长率(0.92±0.21)与对照组(3.48±1.17)、37°C碘油组(1.29±0.26)相比有差异(P<0.05)。60°C碘油组存活期(41.0±3.0)与对照组(31.5±3.0)相比有差异(P<0.05)。60°C碘油组血清AST水平与37°C碘油组相比无差异(P>0.05),与对照组相比有差异(P<0.05)。结论60°C碘油组可降低肿瘤生长率,延长存活期,肝功的损害是可逆的,且抑瘤效果更强。Objective To evaluate the anti-tumour effect of heated Lipiodol in hepatocarcinoma of rabbits.Methods VX_2 carcinoma cells were surgically implanted into the left liver lober of 30 male New Zealand white rabbits ,which were divided into 3 groups at random ,with 10 rabbits for each group.To inject physiological saline,Lipiodol(37℃),Lipiodol(60℃)in different groups via hepatic artery.1 week later the volume of tumour and the serum level of AST was observed.The survival period of VX_2 rabbits was also observed. Results In group of Lipiodol (60℃),the tumour’s growth rate (0.92±0.21)was significantly lower than that in control group(3.48±1.17),and Lipiodol(37℃) groups(1.29±0.26) respectively(P<0.05).The survival period in Lipiodol(60℃)group(41.0±3.0)was significantly higher than that in the other treated group(31.5±3.0)(P<0.05).The serum level of AST in Lipiodol(60℃) group was not higher than that in the other treated group(P>0.05),but was significantly higher than that in the untreated control group after treated(P<0.05).Conclusion Lipiodol(60℃)greatly decreases the tumour’s growth rate ,and prolongs the survival period.In brief ,it is a safety method and has stronger inhibitory effect than other groups.

关 键 词：介入性热化疗 兔 VX2 肝癌 疗效 碘油 

分 类 号：R-332[医药卫生] R735.7