HMRS在星形细胞肿瘤诊断中的应用  

The Study of ~1 HMRS in Diagnosis of Astrocytoma

作　　者：鱼博浪[1] 王斐[1] 郭世萍[1] 孙亲利[1] 

机构地区：[1]西安交通大学第一医院影像中心,陕西西安710061

出　　处：《实用放射学杂志》2005年第6期572-575,共4页Journal of Practical Radiology

基　　金：陕西省科技攻关项目(2004K-12G3)。

摘　　要：目的探讨1HMRS在星形细胞肿瘤分级和鉴别诊断中的价值。方法星形细胞肿瘤58例,包括弥漫性星形细胞瘤18例,间变性星形细胞瘤24例,胶质母细胞瘤16例,均行常规MR和1HMRS检查,统计分析Cho/Cr、Cho/NAA及NAA/Cr比值。结果弥漫性星形细胞瘤表现为Cho轻度升高,NAA和Cr轻度下降,未出现Lac。间变性星形细胞瘤和胶质母细胞瘤均表现为Cho明显升高,NAA及Cr明显下降,6例出现Lac。弥漫性星形细胞瘤Cho/NAA比值为2.72±1.16,Cho/Cr比值为2.66±1.21,NAA/Cr比值为1.02±0.34。间变性星形细胞瘤Cho/NAA比值为5.69±1.32,Cho/Cr比值为4.92±1.46,NAA/Cr比值为0.92±0.16。胶质母细胞瘤Cho/NAA比值为5.71±1.08,Cho/Cr比值为5.12±1.76,NAA/Cr比值为0.87±0.13。结论1HMRS对星形细胞肿瘤分级和鉴别诊断很有价值。Objective To assess the value of ~1 HMRS in the classification and differential diagnosis of astrocytoma. Methods 58 cases of astrocytoma including 18 cases of diffuse astrocytoma, 24 cases of anaplastic astrocytoma and 16 cases of glioblastoma were all examined by routine MR scan and ~1 HMRS, statistical analysis was done on Cho/Cr, Cho/NAA and NAA/Cr ratio. Results Diffuse astrocytoma showed slightly elevated Cho, a bit decreased NAA and Cr. Lac wave did not appear. Anaplastic astrocytoma and glioblastoma both manifested distinctly elevated Cho, obviously decreased NAA and Cr. Lac wave existed in 6 cases. In diffuse astrocytoma the ratio of Cho/NAA was 2.72±1.16, Cho/Cr was 2.66±1.21, NAA/Cr was 1.02±0.34. In anaplastic astrocytoma the ratio of Cho/NAA was 5.69±1.32, Cho/Cr was 4.92±1.46, NAA/Cr was 0.92±0.16. In glioblastoma the value of Cho/NAA was 5.71±1.08, Cho/Cr was 5.12±1.76, NAA/Cr was 0.87±0.13.Conclusion It is very significant of ~1 HMRS in the classification and differential diagnosis of astrocytoma.

关 键 词：氢质子波谱 星形细胞肿瘤 鉴别诊断 

分 类 号：R739.41[医药卫生—肿瘤] R445.2[医药卫生—临床医学]