影响胸腺肿瘤切除与预后的诸因素分析  

ANALYSIS OF THE INFLUENCE FACTORS ON THE RESECTION AND PROGNOSIS OF THYMIC TUMORS

作　　者：张志庸[1] 任华[1] 于洪泉[1] 李泽坚[1] 孙成孚[1] 徐乐天[1] 刘鸿瑞[1] 

机构地区：[1]北京协和医院

出　　处：《中华肿瘤杂志》1994年第5期375-378,共4页Chinese Journal of Oncology

摘　　要：１１０例胸腺瘤行外科手术，其中单纯性胸腺瘤９２例，胸腺类癌８例，胸腺癌１０例。全组５０．９％合并综合征，４４．５％合并重症肌无力（以上皮型最多见），胸腺癌无一例合并重症肌无力。梭形细胞型多合并单纯红细胞再障，５０％胸腺类癌合并异位ＡＣＴＨ综合征。胸腺瘤切除率与肿瘤大小以及周围侵犯有关。单纯胸腺瘤与胸腺类癌和胸腺癌切除率差异有显著性意义，肿瘤外侵严重影响切除率。单纯胸腺瘤３、５和１０年存活率分别为８２．７％、６８．１％和４０．０％。预后与病理分型和外侵有关，重症肌无力对预后影响不大，晚期死亡的主要原因仍是肿瘤复发和转移。Abstract One hundred eleven thymic tumors were intervened surgically ,intervened surgically,including 92 thymoma,8 thymic carcinoid ,and 10 thymic carcinoma .In this series 50.9% of the cases were complicated with various syndrime ,44.5% with myasthenia gravis (MG),more frequently in the epithelial cell type .Pure red cell aplasia ofter associated with the spindle cell thymoma 。Of the thymic carcinoid 50% had ectopic ACTH syndrome。Resection rate correlated with the size and invasion of the tumor.There were significant difference in resection rate among thymoma,thymic carcinoid,and thymic carcinoma. The degree of invasion undoubtely influenced on resection. The 3 ,5 ,and 10 year survival rates of the thymoma were 82.7%,68.1 % and 40.0% respectively . The prognosis depended on the pathological classification and the severity of neighbouring invasion,but MG had no significant effect on prognosis.Recurrence and metastasis of the tumor remained to be the main cause of late death.

关 键 词：胸腺肿瘤 胸腺切除术 重症肌无力 预后 

分 类 号：R736.305[医药卫生—肿瘤]