组织因子、血管内皮生长因子在乳腺癌表达的意义  

Significance of the expression of TF and VEGF in the breast cancer

作　　者：郭艳丽[1] 闫慧明[2] 杨林花[2] 宋善俊[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院血研所,武汉430022 [2]山西医科大学第二临床医学院

出　　处：《山西医科大学学报》2005年第3期301-304,共4页Journal of Shanxi Medical University

摘　　要：目的探讨组织因子(tissuefactor,TF)、血管内皮生长因子(vascularendothelialgrowthfactor,VEGF)在乳腺癌的表达与肿瘤临床和病理的关系。方法用免疫组化方法(S-P法)检测41例乳腺癌手术切除组织中TF和VEGF表达。结果①在有淋巴结转移、远处器官转移组及组织病理低分化组中TF、VEGF、TF和VEGF共表达率明显高于对照组;②TF、VEGF阳性表达率在各年龄组无显著差异。结论TF、VEGF表达与乳腺癌侵袭、转移密切相关,是反映乳腺癌进展和转移潜能的生物学指标,是乳腺癌临床预后的重要指标。TF、VEGF的共表达也为解释TF的促血管生成作用提供了依据。Objective To study the relationship between expression of tissue factor (TF)and vascular endothelial growth factor(VEGF) and clinical pathology in breast cancer. Methods The expression of TF and VEGF in 41 cases of breast cancer was detected by immunohistochemistry S-P method. Results ①The positive rate of TF and VEGF and the co-expressive positive rate of TF and VEGF were higher in the patients with lymphatical metastasis,distant metastasis and lower histological grade than those without (P<0.05). ②Expression of TF and VEGF was not related to patient's age. Conclusion The expression of TF and VEGF has a close relationship with invasion and metastasis in breast cancer. TF and VEGF are good biology indexes indicating their potential ability of development and metastasis,and are the important prognosis indexes of breast cancer. Their expression can also explain the role of TF in the tumor angiogenesis.

关 键 词：凝血致活酶 内皮 血管 血管内皮生长因子 乳腺肿瘤 

分 类 号：R737.9[医药卫生—肿瘤]