柴瓜消结汤对实验性乳腺增生家兔性激素水平的影响  

Clinical and Experimental Study of Chaiguaxiaojie Tang in Treating Hyperplasia of Mammary Gland

作　　者：唐荣[1] 陈静[1] 王海澜[1] 陈金华[1] 张旭[1] 赵勇[1] 杨明 段君英[1] 

机构地区：[1]深圳市龙岗中心医院,广东深圳518116 [2]江西国药有限公司药研所,江西南昌330002

出　　处：《中医药学刊》2005年第6期1098-1100,共3页Study Journal of Traditional Chinese Medicine

摘　　要：目的:探讨柴瓜消结汤治疗乳腺增生病的疗效和对性激素的调节作用。方法:通过动物实验观察柴瓜消结汤治疗乳腺增生病的疗效和性激素的变化。结果:家兔乳腺高度及乳腺直径均较模型对照组有明显缩小;雌二醇(E2)和垂体催乳素(PRL)明显降低(均P<0.05),孕酮(P)和睾酮(T)则有回升(均P<0.05),促卵泡成熟激素(FSH)和促黄体生成素(LH)改变无显著性差异(均P>0.05)。柴瓜消结汤对实验性增生家兔有明显防治作用,能调整家兔体内的性激素分泌。结论:柴瓜消结汤治疗乳腺增生病有显著的临床疗效,并能调整机体内源性激素水平。Objective:To observe the therapeutic effect of chaiguaxiaojie Tang(CGXJ) on hyperplasia of mammary Gland (HMG) and to explore its mechanism in regulating sex hormones. Methods: clinical changes of HMG were observed and serum sex hormones measured before and after CGXJ treatment. In experimental study, the effect of CGXJ was estimated by using electron microscope, pathologic and radioimmunoassay. Rusults :CGXJ could not only cure HMG, but also regulate the sex hormone secretion both in HMG patients and in rats. Clinical study showed that the clinical cure rate was 72% , and the total effective rate was 92%, it demonstrated a significant difference in comparing with the control group, P < 0.05, while progestogen and testosterone increased significantly, P<0.05, but no significantly change of follide-stimulating hormone and luteinizing hormone was found. CGXJ showed marked effect in treating and preventing experimental HMG in rats, it could modulate the sex hormone, and improve the construction of mammary gland. Conclusion :CGXJ has significant effect in treating HMG, it can adjust the endogenous sex hormone level, Delay the development of chronic cystic hyperplasia of mammary gland.

关 键 词：乳腺增生病 柴瓜消结汤 临床统计 药理研究 

分 类 号：R-33[医药卫生]