大剂量纳洛酮联合低分子肝素治疗急性脑梗死的疗效观察  

Clinical Study of the Effects of Naloxone Combined with Low-Molecular-weight Heparin Calcium in Patients with Acute Cerebral Infarction

作　　者：邬志坚[1] 黎丽云[1] 江慧玲[1] 吴丽君[1] 

机构地区：[1]广州市番禺区中医院内科,番禺511400

出　　处：《现代临床医学生物工程学杂志》2005年第2期107-109,共3页Journal of Modern Clinical Medical Bioengineering

摘　　要：目的观察纳洛酮联合低分子肝素治疗急性脑梗死的疗效及安全性.方法急性脑梗死患者78例,按入院先后顺序分成两组,治疗组(n=40)用纳洛酮联合低分子肝素治疗12d,对照组(n=38)应用银杏叶注射液静滴12d.分别观察两组治疗前后血液凝血酶原时间、纤维蛋白原、血小板恢复及临床神经功能评分和日常生活能力(ADC)评分.结果两组凝血酶原时间、纤维蛋白原治疗前无差异(p>0.05),治疗后治疗组明显改善(p<0.01).临床神经功能缺损评分治疗组总有效率及显效率高于对照组(p<0.01),均未发现出血性脑梗死或上消化道出血.结论大剂量纳洛酮联合低分子肝素治疗急性脑梗死安全有效.ObjectiveTo observe the clinical efficiency and safety of large dose of Naloxone combined with low-molecular-weight heparin calcium in patients with acute cerebral infarction. MethodsSeventy-eight patients were randomized equivalenlly divided into treatment group(40 caces) and control group(38 cases).The treatment group was treated with naloxoue and low-molecular-weight heparin calcium for 12d.The control group was treated with injection YinXinYe. ResultsThere were no significant differences in prothrombase time and fibrinogen between the two groups before treatment (p>0.05),while the differences were significant after treatment (18.16±1.59)vs (13.22±1.36)(t=23.914,p<0.01),(2.56±0.78)vs(3.14±0.72)g/L(t=5.417,p<(0.01)).There were no significant difference in blood platelet number between the two groups before and after treatment.The total effective rate and effective of score of clinical neurodynamic impairment in the treatment group were 95% and 75%,and those in control group were 78.9% and 52.6%,there were significant differences between the two groups(p<0.01).No hemorrhagic cerebral infaraction was obsered in both groups or hernorrhagic alimentary canal. ConclusionsThis an effective and safe therapy which treats the acute cerebral infarction by large dose of naloxone combined with low-molecular-weight heparin calcium.

关 键 词：脑梗死 纳洛酮 肝素 低分子量 

分 类 号：R743.3[医药卫生—神经病学与精神病学]