基质金属蛋白酶及其抑制因子在边缘系统胶质瘤中的表达  

The expression of MMPs and TIMPs in gliomas of the limbic system

作　　者：易书贵[1] 陈谦学[2] 王军民[2] 阮航[2] 郑虎[2] 黄乔春[2] 邵步云[2] 

机构地区：[1]湖北省宜昌市中心人民医院神经外科,443003 [2]武汉大学人民医院神经外科

出　　处：《临床外科杂志》2005年第5期298-300,共3页Journal of Clinical Surgery

摘　　要：目的探讨基质金属蛋白酶(MMPs)MMP2、MMP9及其组织抑制因子(TIMPs)TIMP2在边缘系统胶质瘤侵袭过程中的作用。方法利用免疫组织化学方法检测MMP2、MMP9及TIMP2在35例高、低级别胶质瘤和20例脑膜瘤中的表达。结果①MMP2及MMP9在高级别胶质瘤中的表达明显高于低级别胶质瘤,在低级别胶质瘤中的表达明显高于脑膜瘤,差异有显著性。②TIMP2在高级别胶质瘤中的表达明显低于低级别胶质瘤,在低级别胶质瘤中的表达明显低于脑膜瘤,差异有显著性。结论①MMP2及MMP9的表达与胶质瘤的恶性程度有关,可能成为胶质瘤恶性程度和预后的判断指标。②TIMP2是MMP2的抑制因子,两者之间失衡是促进胶质瘤侵袭的重要因素之一。Objective To investigate the function of matrix metalloproteinase-2(MMP-2),matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloproteinase-2 (TIMP-2) in the invasion of gliomas of the limbic system.Methods The expression of MMP-2,MMP-9 and TIMP-2 in low and high-grade gliomas and meningiomas was detected by using immunohistochemical technique.Results (1) The expression levels of MMP-2 and MMP-9 were significantly higher in high grade gliomas than those in low grade gliomas (P<0.05 and P<0.01 respectively).They were also significantly higher in low grade gliomas than those in meningiomas (P<0.05 and P<0.01 respectively).(2) The TIMP-2 expression level was obviously lower in gliomas of grade III and grade IV than that in gliomas of grade I and grade II.Also,the expression of TIMP-2 in gliomas of grade I and grade II was significantly lower than that in meningiomas.Conclusion (1) The expression of MMP-2 and MMP-9 in human brain gliomas is related to malignant progression of gliomas.They might be used as the indicators to evaluate the malignancy and prognosis of gliomas.(2) Imbalance between MMP-s and TIMP-s may be one of the important factors promoting glioma invasion.

关 键 词：基质金属蛋白酶 基质金属蛋白酶组织抑制因子 胶质瘤 边缘系统 

分 类 号：R739.4[医药卫生—肿瘤]