胃癌组织中Bag-1和Bcl-2的表达及意义  

Expression of Bag-1 and Bcl-2 and its significance in gastric cancer

作　　者：王文勇[1] 唐红卫[2] 张志培[1] 韩彬[2] 高艳红[2] 马福成[1] 闫庆国[1] 赵一岭[1] 

机构地区：[1]中国人民解放军第四军医大学西京医院病理科,陕西省西安市710033 [2]中国人民武装警察部队总医院消化内科,北京市100039

出　　处：《世界华人消化杂志》2005年第10期1186-1189,共4页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助课题;No.39270744~~

摘　　要：目的:探讨Bag-1和Bcl-2蛋白在胃癌组织中的表达及其临床意义. 方法:胃癌患者术后组织标本92例,运用免疫组织化学的方法检测Bag-1和Bcl-2蛋白的表达,并以40例正常胃黏膜组织作对照. 结果:胃癌组织Bag-1和Bcl-2蛋白的表达明显增高(60.9% vs7.5%,72.8%vs 10%,P均<0.01),并且Bcl-2表达与胃癌分化程度相关(rs=0.513,P<0.05).胃癌组织中Bag-1表达与Bcl-2表达相关非常显著(rs=0.522,P<0.01). 结论:Bcl-2通过促进细胞的转化和增生及抑制细胞的凋亡,使GC呈现无限制的生长及恶性程度不断增高; Bag-1具有促进Bcl-2功能的作用;Bag-1和Bcl-2的共表达可能预示胃癌患者预后不良.AIM: To investigate the expression of Bag-1 and Bcl-2 protein and its clinical significance in gastric cancer (GC). METHODS: Immunohistochemistry was used to detect the expressison of Bag-1 and Bcl-2 protein in 92 patients with gastric cancer and 40 normal tissues as control. RESULTS: Compared with normal mucosa, Bag-1 and Bcl-2 were over-expressed in gastric cancerous tissues (60.9% vs7.5%, 72.8% vs 10%, P<0.01). The expression of Bcl-2 protein was significantly correlated with the differentiation degree (rs=0.513, P<0.05) and the expression of Bag-1 was significantly associated with Bcl-2 level in gastric cancer (rs= 0.522, P<0.01). CONCLUSION: The over-expression of Bcl-2 leads to uncontrolled growth and unceasingly increases of GC cells by accelerating cell transformation and proliferation. Bag-1 promotes the function of Bcl-2 and co-expression of Bag-1 and Bcl-2 may mean poor prognosis of GC patients.

关 键 词：BAG-1 胃癌组织 表达及 Bcl-2蛋白 BCL-2表达 免疫组织化学 胃癌患者 胃黏膜组织 组织标本 临床意义 分化程度 抑制细胞 恶性程度 预后不良 共表达 增高 相关 

分 类 号：R735.2[医药卫生—肿瘤]