薏苡仁酯对人鼻咽癌细胞裸鼠移植瘤的放射增敏作用  

Increased radiosensitivity of transplanted human nasopharyngeal carcinoma in nude mice by coixenolide

作　　者：李毓[1] 胡笑克[2] 

机构地区：[1]广东省中医研究所,广东广州510095 [2]中山医科大学核医学教研室,广东广州510089

出　　处：《华夏医学》2005年第2期147-148,共2页Acta Medicinae Sinica

基　　金：广东省自然科学基金 (970 83 9) ;广东省中医药管理局 (972 66)资助课题。

摘　　要：目的:探讨薏苡仁酯(coixenolide,CXL )对人鼻咽癌细胞裸鼠移植瘤辐射效应的影响。方法:将该肿瘤细胞株CNE- 2 Z移植到裸鼠,成瘤后经CXL预处理再进行γ射线外照射。结果:CXL以量效方式提高移植瘤的放射敏感性。与对照组比较,肿瘤生长缓慢,放射损伤修复时间延长。放射增敏率7.1 9%～2 6 .2 8%。结论:CXL 对人鼻咽癌细胞裸鼠移植瘤具有放射增敏作用。Objective: To study the effect of coixenolide(CXL)on irradiation to laboratory-produced human nasopharyngealcarcinoma. Methods: Tumor cell line CNE-2Z was transplanted to nude mice for determining susceptibility to γ-ray and the effect of the drag on radiation. Results: CXL aggravated the tumor-transplanted damage after irradiation in adose-dependent fashion, which exhibited the tumor growth was slower and the time of damage repair longer than control. The sensitizing enhancement ratios were 7.19%~26.28%.Conclusion: CXL can increase the tumor radiosensitivity.

关 键 词：鼻咽肿瘤 异种移植 裸鼠 薏苡仁酯 放射增敏 

分 类 号：R739.63[医药卫生—肿瘤] R445.2[医药卫生—临床医学]