胃动脉内化疗药物灌注合用栓塞病理学研究  

Pathological Study of Gastric Chemotherapeutic Drugs Infusion or/and Embolization in Rabbits

作　　者：李茂全[1] 林贵[1] 胡锡淇 王小林[1] 

机构地区：[1]上海医科大学附属中山医院放射科,上海医科大学病理学教研室

出　　处：《肿瘤》1994年第1期29-31,共3页Tumor

摘　　要：本文报告了１６例正常新西兰白兔采用胃动脉内灌注（Ｇａｓｔｒｉｃ　ａｒｔｅｒｉａｌ　ｉｎｆｕｓｉｏｎ，ＧＡＩ）化疗药物与合用栓塞（Ｇａｓｔｒｉｃ　ａｒｔｅｒｉａｌ　ｉｎｆｕｓｉｏｎ　ａｎｄ　ｅｍｂｏｌｉｚａｔｉｏｎ，ＧＡＩ＋ＧＡＥ）两种方法的病理学结果。结果显示：ＧＡＩ与ＧＡＩ＋ＧＡＥ均对胃组织有一定损伤，以ＧＡＩ＋ＧＡＥ组为重，损伤局限于粘膜层和粘膜下层、肌层和浆膜正常，未见消化道大出血及胃穿孔。术后３０～４５天，两组均表现正常。说明：ＧＡＩ＋ＧＡＥ可能开发成为又一个可供选择的治疗晚期胃癌的新方法。Seven New Zealand white rabbits were treated by gastric arterial infusion (GAI) with chemotherapeutic drugs and another seven by gastric arterial infusion and embolization(GAI+GAE). The result indicated that GAI+GAE injured the gastric tissue much more than GAI did. The GAI caused a slight edema and inflammation while GAI+GAE raised acute inflammation, edema and focal necrosis in mucosa and submucosa but spared the muscular and serous layers. Recovery occurred within 30 to 45 days. The result demonstrated that GAI+GAE management could be practicable for treating advanced gastric cancer. It had no possibility of gastric perforation.

关 键 词：病理学 GAI 药物疗法 胃肿瘤 

分 类 号：R735.205[医药卫生—肿瘤]