胃癌患者止血异常与血栓形成意义的探讨  

STUDIES OF ABNORMAL COAGULATION AND THROMBOSIS IN PATIENTS WITH GASTRIC CANCER

作　　者：熊树民[1] 王鸿利[1] 颜纪贤[1] 邵慧珍[1] 陈怡群[1] 李海棠[1] 

机构地区：[1]上海第二医科大学瑞金医院,上海第二医科大学宝钢医院

出　　处：《肿瘤》1994年第3期155-157,共3页Tumor

摘　　要：本文测定２１例胃癌患者血浆中止凝血和抗凝、纤溶的有关指标，并对术前术后的检测结果进行比较，发现胃癌患者血浆中ＴＸＢ２、６－Ｋｅｔｏ－ＰＧＦｌα含量增高，ＴＸＢ２／６－Ｋｅｔｏ－ＰＧＦｌα比值失调，ｖＷＦ：Ａｇ升高，Ⅷ：Ｃ／ＶＷＦ：Ａｇ比值减低，ＡＴ－Ⅲ：Ａ、ＰＣ：Ａ明显下降，ＦⅡ：Ａ增高，胃癌术前ＦＤＰ明显升高，术后正常，提示这些变化可能与胃癌的生长和转移有关。Ｐ＜０．０１，＊Ｐ＜０．００１；▲术前术后有差别：▲Ｐ＜０．０５，▲▲Ｐ＜０．０１，▲▲▲Ｐ＜０．００１讨论恶性肿瘤是一团不断生长、难以遏制的细胞，并能转移。作为繁衍的条件，肿瘤细胞受到癌基因表达的某些生长因子的刺激，癌能分泌血管生成因子（Ｔｕｍｏｒａｎｇｉｏｇｅｎｅｔｉｃｆａｃｔｏｒ，ＴＡＦ）营造自身血管系统。恶性肿瘤之所以转移是由于肿瘤细胞具有某种逃避生理性或免疫性监控系统的能力。它们能分泌某些酶，降解细胞外间质（Ｅｘｔｒａｃｅｌｌｕｌａｒｍａｔｒｉｘ，ＥＣＭ）、解除血管、淋巴管以及结缔组织的拦阻。肿瘤细胞的这些特征可能反映为某些止血因子和血栓形成因子的异常。一、恶性肿瘤患者的皿液常处于血栓前状态，易于发生血栓。已知胃癌病人静脉血栓形成发生率高达?The authors studied the changes of plasmatic coagulation, anticoagulation and fibrinolysis in 21 paitients with gastric cancer before and after gastric operation.The results shwed: TXB2,6-keto-PGFIα,vWF:Ag and FⅡ:A levels in cancer patients were increased.The plasmatic AT-Ⅲ activity and PC;A levels were sigi1ificantly decreased.The ratio of TXB2/6-keto-PGFIαand vWF: Ag/FⅧ:C were abnormal. Before operation the patients had high FDP levels,but dropped to normal after operation. Our studies suggested that these chages of plasmatic parameter might be correlated with the growth and metastasis of gastric cancer.

关 键 词：血栓前状态 胃肿瘤 血栓形成 

分 类 号：R735.2[医药卫生—肿瘤]