女性肺癌对雌、孕激素受体的依赖及受体与预后的关系─附57例临床病理研究  

The Dependence of Female Lung Cancer on Estrogen and Prgestogen Receptor and The Relation Between The Receptors and Prognosis

作　　者：臧旺福[1] 陈云富[1] 孙秀威[1] 鄢凤昌[1] 冯占军[1] 

机构地区：[1]哈尔滨医科大学附属第三医院胸外科,哈尔滨医科大学附属第三医院病理科

出　　处：《肿瘤防治研究》1994年第2期76-78,共3页Cancer Research on Prevention and Treatment

摘　　要：本文用免疫组化法（改良ＰＡＰ法），检测５７例女性肺癌组织，５例正常肺组织和５例肺炎性假瘤组织（对照组）的雌激素受体（ＥＲ）和孕激素受体（ＰＲ）。结果证实女性肺癌组织内存在ＥＲ和ＰＲ，其阳性率分别为４２．１％和５４．４％，而对照组未发现ＥＲ和ＰＲ。ＥＲ、ＰＲ阳性的女肺癌术后５年生存率较阴性者高（（Ｐ＜０．０５）；ＥＲ、ＰＲ阳性的女性肺癌术后化疗效果较阴性者好（Ｐ＜０．０５），ＥＲ、ＰＲ的表达与肺癌的临床分期、瘤体大小、年龄、闭经与否无明显关系（Ｐ＞０．０５）。We have used immunohistochemical method(an improved PAP method) to determine estrogen receptor(ER) and progestogen receptor(PR) in 57 female cases with lung cancer tissue, 5 eases with normal lung tissue and 5 cases with lung inflammatory pseudotumor tissue. Result proved that positive rate in female lung cancer tissue with ER and PR were 42.1% and 54. 4% respectively. while no ER and PR in control group. 5-year survival rate of patients with ER and PR positive female lung cancer after operation was higher than those with negative ones(P<0. 05). 5-yearsurvival rate of ER and PR positive female lung cancer treated by chemotherapy after operation was also higher than those of negative ones(P<0. 05). The ER and PR expression was not obviously associated with climcal classifications of lung cancer, the type of tissue, the size of tumor, age nor amenorrhea of not(P<0. 05).

关 键 词：癌 雌激素 受体 孕激素 肺肿瘤 

分 类 号：R734.2[医药卫生—肿瘤]