Langerhans细胞浸润与胃癌转移及分化程度关系的定量研究  

Quantitative study of Relation Between Langerhans Cells Invasion and Metastasis and Differentiation of Gastric Carcinoma

作　　者：喻伦银[1] 刘汉桥[1] 徐江[1] 李蓓芸[1] 邹祖玉[1] 凌长明[1] 

机构地区：[1]湖北医科大学病理学教研室,铁道部武昌车辆厂医院

出　　处：《肿瘤防治研究》1994年第5期272-273,共2页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金

摘　　要：Ｌａｎｇｅｒｈａｎｓ细胞（ＬＣ）是一种骨髓来源的具有免疫辅助功能的细胞，与肿瘤有一定的关系。本研究用免疫组织化学方法利用Ｓ－１００蛋白抗体对６５例胃癌组织中的ＬＣ进行了定量研究，以探讨肿瘤组织中ＬＣ的浸润与胃癌转移及分化程度的关系。结果表明，癌组织中ＬＣ浸润明显的患者，其局部淋巴结癌转移发生频率明显低于无ＬＣ浸润或ＬＣ浸润不明显者。３５例无淋巴结转移的患者癌组织中均可见ＬＣ浸润，而有淋巴结转移的３０例癌组织中只有９例可见ＬＣ浸润。另外，本研究还观察到分化程度高的癌组织中ＬＣ浸润较为明显，在１５例高分化癌组织中均可见ＬＣ浸润，１８例中分化的癌组织中有１４Ｎ可见ＬＣ浸润，而低分化的３２例癌组织中只有５例可见ＬＣ浸润。本研究结果提示ＬＣ浸润与胃癌转移和分化程度确有密切的关系。The bone marrow-derived Langerhans cells (LC) are antigen-Presenting accessory cells functioning as part as the immune system and relate to tumors to a certain extent' In the presentstudy, the quantitative analysis of LC invasion in sixty five tissues of gastric cardnoma was carried out with immunohistochemistry method to probe the relationship b et ween LC invas ion andmetastasis and differentiation of tumors. The results showed that the markedly invasion of LCwas observed in the tissues from the patients without cancer metastasis in the regional lymphnodes; LC invasion was seen in all of 35 ti88ues from the patients without the metastasis, but only9 out of 32 samples from the patients with the metastasis. In addition, the significant LC invasioncould be observed a18o in 15 of 15 well differentiated cancer tissues and 14 of 18 moderately differentiated, but only 5 out of 32 poorly differentiated. The results suggested that LC invasion incancer tissues relates to the metastasis and differentiation of gastric carcinoma significantly.

关 键 词：郎格汉 胃肿瘤 癌 转移 分化 免疫组织化学 

分 类 号：R735.203[医药卫生—肿瘤] R730.45[医药卫生—临床医学]