同种异品系输血对小鼠B_（16）黑色素瘤肺转移的促进作用  

Acceleration of Allogeneic Blood Transfusion on B_(16) Melanoma Metastasis

作　　者：吴强[1] 张林杰[1] 姚立人[1] 

机构地区：[1]潍坊医学院免疫学教研室,安徽医科大学病理生理学教研室

出　　处：《肿瘤防治研究》1994年第5期278-279,共2页Cancer Research on Prevention and Treatment

摘　　要：首先相隔７天，经球后静脉两次给Ｃ５７ＢＬ／６Ｊ小鼠注射生理盐水，同种同品系或同种异品系小鼠全血。于第２次输注后第７天，经球后静脉注射Ｂ（１６）黑色素瘤单细胞悬液，并在体外检测自然杀伤细胞活性和淋巴细胞转化率。结果表明，同种异品系间的输血，可明显降低受者的自然杀伤细胞活性和淋巴细胞转化，并促进肿瘤的肺转移。而同种同品系间的输血则无此不良影响。本文提示，Ｈ－２不相容性输血可促进肿瘤转移，免疫功能下降是输血促进肿瘤转移的重要因素之一。C57BL/6J mice were given infusion of saline solution, syngeneic blood, allogeneic blood atfirst and sib day' At 7th day after the second infusion, a single cell suspension of B16 melanomawas injected via the retro-orbital veins into C57BL/6) mice and both NK activity and proliferativeresponse of splenocytes were tested in vitro. The result showed that metastasis were significantlyincreased and both NK activity and preliferative response of splenocytes were markedly depressedin allogeneic blood-transfused mice. There were no evidences of acceleration of tumor spread andsuppression of cellmediated immune response when those animals were transfused with syngeneicblood. It is suggested that the acceleration of metastasis seen following H-2-incompatible allogeneic blood transfusions appears to be related to trans fusion-induced immunosuppression.

关 键 词：输血 黑色素瘤 肿瘤转移 细胞免疫 

分 类 号：R739.5－37[医药卫生—肿瘤]